| Type | Description |
|---|---|
| Definition | complement C8 alpha chain |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:37:00 | A Point Mutation Creating a 3' Splice Site in C8A Is a Predominant Cause of C8alpha-gamma Deficiency in African Americans. | 32769119 |
| 2019-08-24 10:10:00 | These data provide a detailed specification of co-occurring C8 proteoforms, including experimental evidence on N-glycosylation, C-mannosylation, and O-glycosylation. | 29532326 |
| 2012-11-19 10:57:00 | C8 alpha and C8 beta have correspondingly similar roles in MAC-mediated lysis of erythrocytes and bacterial killing. C8 gamma is not required for complement-mediated killing of Gram-negative bacteria. | 12413696 |
| 2012-11-19 10:56:00 | Results describe the crystal structure of the human C8 alpha MACPF domain disulfide-linked to C8 gamma (alphaMACPF-gamma) at 2.15 A resolution. | 18440555 |
| 2010-09-15 22:06:00 | Observational study of gene-disease association. (HuGE Navigator) | 19913121 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
CO8A_HUMAN
UniprotKB:
P07357
UniParc:
UPI0000127C5A
EMBL:
U08003,
M16974,
U08002,
U08000,
U07996,
U07998,
U08004,
U07997,
U08006,
BC132913,
U08001,
BC132911,
AL121998,
U07999,
U08005
Ensembl:
ENSG00000157131
KO:
hsa:731
|
| Nucleutide sequences |
EMBL-CDS:
AAA82124.1,
AAI32912.1,
AAA52200.1,
AAI32914.1
Ensembl_TRS:
ENST00000361249
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000354458
RefSeq:
NP_000553.1,
XP_016857723.1,
XP_011540381.1
|
| Others |
UniRef100:
UniRef100_P07357
UniRef90:
UniRef90_P07357
UniRef50:
UniRef50_P07357
UniGene:
Hs.93210
CCDS:
CCDS606.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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