| Type | Description |
|---|---|
| Definition | insulin induced gene 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-11 12:05:00 | Insig-2 is an ER membrane protein negatively controlling lipid biosynthesis. The stabilized Insig-2 downregulates lipogenesis through inhibiting the SREBP pathway, helping to channel the carbon flux to ATP generation and protecting myotubes from lipid over-accumulation. | 31953408 |
| 2019-06-15 11:39:00 | CRTC2 modulates hepatic SREBP1c cleavage by controlling Insig2a expression during fasting | 29679236 |
| 2019-04-27 11:11:00 | These results suggest that PPARalpha is a trans-acting factor that enhances Insig2a gene expression, thereby suppressing SREBP-1c processing during fasting. | 28855656 |
| 2018-08-04 10:08:00 | Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. | 29899135 |
| 2017-07-01 11:00:00 | INSIG2 is a negative regulator of SREBP, and acute glucocorticoid treatment decreased active SREBP during refeeding or in livers of Ob/Ob mice, both systems of elevated SREBP-1c-driven lipogenesis. | 27568546 |
| Type | IDs |
|---|---|
| Synonymous | 2900053I11Rik, C730043J18Rik, Insig-2 |
| Gene |
UniProtKB-ID:
INSI2_MOUSE,
A0A087WQP7_MOUSE
UniprotKB:
Q91WG1,
A0A087WQP7
UniParc:
UPI0000020D82,
UPI00001ED54D
EMBL:
AK050394,
BC023067,
AC163333,
AK152076,
AK161256,
AF527631,
BC024411,
AK154543,
BC015288,
BC023874,
AK165634,
AK040703
Ensembl:
ENSMUSG00000003721
KO:
mmu:72999
|
| Nucleutide sequences |
EMBL-CDS:
AAH24411.1,
AAH23874.1,
BAE38307.1,
BAC34233.1,
BAE30928.1,
BAE32667.1,
AAN28332.1,
BAE36273.1,
AAH23067.1,
BAC30676.1,
AAH15288.1
Ensembl_TRS:
ENSMUST00000071064,
ENSMUST00000159085,
ENSMUST00000003818,
ENSMUST00000160968,
ENSMUST00000186915
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000124345,
ENSMUSP00000065485,
ENSMUSP00000123747,
ENSMUSP00000003818,
ENSMUSP00000140292
RefSeq:
NP_001258460.1,
NP_835183.1,
NP_001258461.1,
NP_001344180.1,
XP_006529955.1,
XP_006529952.1,
XP_006529954.1,
NP_598509.1
|
| Others |
UniRef100:
UniRef100_Q91WG1
UniRef90:
UniRef90_Q91WG1
UniRef50:
UniRef50_Q91WG1
UniGene:
Mm.27136,
Mm.486216
CCDS:
CCDS15236.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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