Top1mt - DNA topoisomerase 1, mitochondrial-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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72960 Top1mt

基因描述

Type	Description
Definition	DNA topoisomerase 1, mitochondrial

研究结论

Date	Results	Publications
2019-02-23 13:15:00	Study demonstrated that lack of TOP1MT results in delayed and decreased tumor growth due to impaired mitochondrial translation. The TOP1MT genomic signature profile, based on mouse model for Top1mt-KO liver cancers, is correlated with enhanced survival of hepatocellular carcinoma patients.	30622257
2018-01-06 12:26:00	TOP1MT acts as a topological barrier and regulator for mtDNA transcription and D-loop formation	29021209

名称对应

Type	IDs
Synonymous	2900052H09Rik
Gene	UniProtKB-ID: TOP1M_MOUSE UniprotKB: Q8R4U6 UniParc: UPI00000286A8 EMBL: BC138583, CH466545, AK147119, AF362952, BC138582 Ensembl: ENSMUSG00000000934 KO: mmu:72960
Nucleutide sequences	EMBL-CDS: AAM00270.1, EDL29483.1, AAI38584.1, AAI38583.1, BAE27691.1 Ensembl_TRS: ENSMUST00000000958
Protein sequencees	Ensembl_PRO: ENSMUSP00000000958 RefSeq: NP_001342518.1, XP_036015505.1, NP_082680.1
Others	UniRef100: UniRef100_Q8R4U6 UniRef90: UniRef90_Q8R4U6 UniRef50: UniRef50_Q8R4U6 UniGene: Mm.182401 CCDS: CCDS27547.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
32325033	BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Cell Syst Reza Pourhaghighi , Peter E A Ash , Sadhna Phanse , Florian Goebels , Lucas Z M Hu , Siwei Chen , Yingying Zhang , Shayne D Wierbowski , Samantha Boudeau , Mohamed T Moutaoufik , Ramy H Malty , Edyta Malolepsza , Kalliopi Tsafou , Aparna Nathan , Graham Cromar , Hongbo Guo , Ali Al Abdullatif , Daniel J Apicco , Lindsay A Becker , Aaron D Gitler , Stefan M Pulst , Ahmed Youssef , Ryan Hekman , Pierre C Havugimana , Carl A White , Benjamin C Blum , Antonia Ratti , Camron D Bryant , John Parkinson , Kasper Lage , Mohan Babu , Haiyuan Yu , Gary D Bader , Benjamin Wolozin , Andrew Emili	2020-04-22	-
30622257	The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis. Nat Commun S A Baechler , V M Factor , I Dalla Rosa , A Ravji , D Becker , S Khiati , L M Miller Jenkins , M Lang , C Sourbier , S A Michaels , L M Neckers , H L Zhang , A Spinazzola , S N Huang , J U Marquardt , Y Pommier	2019-01-08	-
29021209	Transcription profiling suggests that mitochondrial topoisomerase IB acts as a topological barrier and regulator of mitochondrial DNA transcription. J Biol Chem Ilaria Dalla Rosa , Hongliang Zhang , Salim Khiati , Xiaolin Wu , Yves Pommier	2017-12-08	-
26305952	Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration. Proc. Natl. Acad. Sci. U.S.A. Salim Khiati , Simone A Baechler , Valentina M Factor , Hongliang Zhang , Shar-yin N Huang , Ilaria Dalla Rosa , Carole Sourbier , Leonard Neckers , Snorri S Thorgeirsson , Yves Pommier	2015-09-08	-
24803675	Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIÎ± and IIÎ² in vertebrate mitochondria. Nucleic Acids Res. Hongliang Zhang , Yong-Wei Zhang , Takehiro Yasukawa , Ilaria Dalla Rosa , Salim Khiati , Yves Pommier	2014-06-01	-
23982517	Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I. Nucleic Acids Res. Stefan Sobek , Ilaria Dalla Rosa , Yves Pommier , Beatrice Bornholz , Faiza Kalfalah , Hongliang Zhang , Rudolf J Wiesner , JÃ¼rgen-Christoph von Kleist-Retzow , Frank Hillebrand , Heiner Schaal , Christian Mielke , Morten O Christensen , Fritz Boege	2013-11-01	Top1mt
22911747	Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism. PLoS ONE CÃ©line Douarre , Carole Sourbier , Ilaria Dalla Rosa , Benu Brata Das , Christophe E Redon , Hongliang Zhang , Len Neckers , Yves Pommier	2012-01-01	Top1, Top1mt
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
21677750	A conditional knockout resource for the genome-wide study of mouse gene function. Nature William C Skarnes , Barry Rosen , Anthony P West , Manousos Koutsourakis , Wendy Bushell , Vivek Iyer , Alejandro O Mujica , Mark Thomas , Jennifer Harrow , Tony Cox , David Jackson , Jessica Severin , Patrick Biggs , Jun Fu , Michael Nefedov , Pieter J de Jong , A Francis Stewart , Allan Bradley	2011-06-15	-
21267068	A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. Graciana Diez-Roux , Sandro Banfi , Marc Sultan , Lars Geffers , Santosh Anand , David Rozado , Alon Magen , Elena Canidio , Massimiliano Pagani , Ivana Peluso , Nathalie Lin-Marq , Muriel Koch , Marchesa Bilio , Immacolata Cantiello , Roberta Verde , Cristian De Masi , Salvatore A Bianchi , Juliette Cicchini , Elodie Perroud , Shprese Mehmeti , Emilie Dagand , Sabine Schrinner , Asja NÃ¼rnberger , Katja Schmidt , Katja Metz , Christina Zwingmann , Norbert Brieske , Cindy Springer , Ana Martinez Hernandez , Sarah Herzog , Frauke Grabbe , Cornelia Sieverding , Barbara Fischer , Kathrin Schrader , Maren Brockmeyer , Sarah Dettmer , Christin Helbig , Violaine Alunni , Marie-Annick Battaini , Carole Mura , Charlotte N Henrichsen , Raquel Garcia-Lopez , Diego Echevarria , Eduardo Puelles , Elena Garcia-Calero , Stefan Kruse , Markus Uhr , Christine Kauck , Guangjie Feng , Nestor Milyaev , Chuang Kee Ong , Lalit Kumar , MeiSze Lam , Colin A Semple , Attila Gyenesei , Stefan Mundlos , Uwe Radelof , Hans Lehrach , Paolo Sarmientos , Alexandre Reymond , Duncan R Davidson , Pascal DollÃ© , Stylianos E Antonarakis , Marie-Laure Yaspo , Salvador Martinez , Richard A Baldock , Gregor Eichele , Andrea Ballabio	2011-01-18	-

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