| Type | Description |
|---|---|
| Definition | TXK tyrosine kinase |
| Date | Results | Publications |
|---|---|---|
| 2015-05-23 12:33:00 | These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK and RLK, and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo. | 25593320 |
| 2010-12-05 22:08:00 | Observational study of gene-disease association. (HuGE Navigator) | 20800603 |
| 2010-09-15 22:05:00 | Observational study of gene-disease association. (HuGE Navigator) | 19913121 |
| 2010-09-15 22:05:00 | Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | 20628086 |
| 2010-06-30 22:05:00 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | 20379614 |
| Type | IDs |
|---|---|
| Synonymous | BTKL, PSCTK5, PTK4, RLK, TKL |
| Gene |
UniProtKB-ID:
TXK_HUMAN
UniprotKB:
P42681
UniParc:
UPI000013D4F9
EMBL:
U34372,
U34368,
U34378,
U34377,
U34371,
U34370,
U34367,
U34369,
U34373,
U34375,
L27071,
U34376,
U34379,
U34374
Ensembl:
ENSG00000074966
KO:
hsa:7294
|
| Nucleutide sequences |
EMBL-CDS:
AAB60412.1,
AAA74557.1
Ensembl_TRS:
ENST00000264316
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000264316
RefSeq:
XP_024309968.1,
XP_011512050.1,
XP_016864070.1,
XP_016864071.1,
XP_011512049.1,
NP_003319.2
|
| Others |
UniRef100:
UniRef100_P42681
UniRef90:
UniRef90_P42681
UniRef50:
UniRef50_P42681
UniGene:
Hs.479669
CCDS:
CCDS3480.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32296183 |
A reference map of the human binary protein interactome. Nature Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G Coté , Meaghan Daley , Steven Deimling , Alice Desbuleux , Amélie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , István A Kovács , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat TaÅan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood |
2020-04-01 | - |
| 31586073 |
The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Nat Commun Luisa Capalbo , Zuni I Bassi , Marco Geymonat , Sofia Todesca , Liviu Copoiu , Anton J Enright , Giuliano Callaini , Maria Giovanna Riparbelli , Lu Yu , Jyoti S Choudhary , Enrico Ferrero , Sally Wheatley , Max E Douglas , Masanori Mishima , Pier Paolo D'Avino |
2019-10-04 | - |
| 25593320 |
J Biol Chem Yiming Zhong , Shuai Dong , Ethan Strattan , Li Ren , Jonathan P Butchar , Kelsey Thornton , Anjali Mishra , Pierluigi Porcu , J Michael Bradshaw , Angelina Bisconte , Timothy D Owens , Erik Verner , Ken A Brameld , Jens Oliver Funk , Ronald J Hill , Amy J Johnson , Jason A Dubovsky |
2015-03-06 | - |
| 25814554 |
Phospho-tyrosine dependent protein-protein interaction network. Mol. Syst. Biol. Arndt Grossmann , Nouhad Benlasfer , Petra Birth , Anna Hegele , Franziska Wachsmuth , Luise Apelt , Ulrich Stelzl |
2015-03-01 |
SH2B3,
SH2D3A,
HUWE1,
FSBP,
TSPAN2,
TNK2,
SPRY2,
APBB3,
TRDN,
ANAPC10,
BAIAP2,
ZNHIT1,
SEMA4D,
UBD,
CENPB,
POLR3F,
RAI2,
SDCCAG8,
FRS3,
FRS2,
PGRMC1,
CYP46A1,
ARID5A,
NMU,
RALBP1,
YWHAQ,
LECT1,
CYB561D2,
RCAN3,
CAPN10,
FSTL1,
RASSF1,
CHN2,
TP53RK,
EFHC1,
OSBPL6,
C1QTNF3,
DDIT4L,
FAM46B,
CKM,
TM4SF19,
RBP7,
OLIG1,
CLNK,
SH2D1B,
TWIST2,
ASCL4,
SOCS4,
COX6B2,
GABPB2,
SHE,
VSTM2L,
C22orf39,
PPP1R21,
SCLT1,
PACRGL,
SETD9,
C6orf141,
MAGEC3,
DCAF12L1,
CRK,
CRKL,
CRP,
TCP10L,
ASB8,
ASB9,
CRYBA2,
CSK,
DUSP18,
FAM117B,
PLB1,
IQUB,
WBSCR27,
CYP2C8,
DBN1,
PAQR7,
DDX5,
LIX1,
GLIS3,
DOK1,
EPYC,
DTNA,
E2F2,
E2F6,
PHC2,
KRTCAP2,
ELK1,
ADCK5,
EPS8,
AKT1,
ESD,
MECOM,
EYA3,
EZH2,
FABP7,
FANCG,
MPEG1,
LNX2,
FAM217A
|
| 24728074 |
Mol Cell Proteomics Kin K Leung , Ronald J Hause , John L Barkinge , Mark F Ciaccio , Chih-Pin Chuu , Richard B Jones |
2014-07-01 | - |
| 23128233 |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature Luke Jostins , Stephan Ripke , Rinse K Weersma , Richard H Duerr , Dermot P McGovern , Ken Y Hui , James C Lee , L Philip Schumm , Yashoda Sharma , Carl A Anderson , Jonah Essers , Mitja Mitrovic , Kaida Ning , Isabelle Cleynen , Emilie Theatre , Sarah L Spain , Soumya Raychaudhuri , Philippe Goyette , Zhi Wei , Clara Abraham , Jean-Paul Achkar , Tariq Ahmad , Leila Amininejad , Ashwin N Ananthakrishnan , Vibeke Andersen , Jane M Andrews , Leonard Baidoo , Tobias Balschun , Peter A Bampton , Alain Bitton , Gabrielle Boucher , Stephan Brand , Carsten Büning , Ariella Cohain , Sven Cichon , Mauro D'Amato , Dirk De Jong , Kathy L Devaney , Marla Dubinsky , Cathryn Edwards , David Ellinghaus , Lynnette R Ferguson , Denis Franchimont , Karin Fransen , Richard Gearry , Michel Georges , Christian Gieger , Jürgen Glas , Talin Haritunians , Ailsa Hart , Chris Hawkey , Matija Hedl , Xinli Hu , Tom H Karlsen , Limas Kupcinskas , Subra Kugathasan , Anna Latiano , Debby Laukens , Ian C Lawrance , Charlie W Lees , Edouard Louis , Gillian Mahy , John Mansfield , Angharad R Morgan , Craig Mowat , William Newman , Orazio Palmieri , Cyriel Y Ponsioen , Uros Potocnik , Natalie J Prescott , Miguel Regueiro , Jerome I Rotter , Richard K Russell , Jeremy D Sanderson , Miquel Sans , Jack Satsangi , Stefan Schreiber , Lisa A Simms , Jurgita Sventoraityte , Stephan R Targan , Kent D Taylor , Mark Tremelling , Hein W Verspaget , Martine De Vos , Cisca Wijmenga , David C Wilson , Juliane Winkelmann , Ramnik J Xavier , Sebastian Zeissig , Bin Zhang , Clarence K Zhang , Hongyu Zhao , International IBD Genetics Consortium (IIBDGC) , Mark S Silverberg , Vito Annese , Hakon Hakonarson , Steven R Brant , Graham Radford-Smith , Christopher G Mathew , John D Rioux , Eric E Schadt , Mark J Daly , Andre Franke , Miles Parkes , Severine Vermeire , Jeffrey C Barrett , Judy H Cho |
2012-11-01 | - |
| 22623531 |
Functional genomics identifies therapeutic targets for MYC-driven cancer. Proc. Natl. Acad. Sci. U.S.A. Masafumi Toyoshima , Heather L Howie , Maki Imakura , Ryan M Walsh , James E Annis , Aaron N Chang , Jason Frazier , B Nelson Chau , Andrey Loboda , Peter S Linsley , Michele A Cleary , Julie R Park , Carla Grandori |
2012-06-12 |
CDH5,
NR1H3,
CDK2,
TRIB1,
SPEG,
ARFGEF2,
SLC25A26,
C17orf49,
CPS1,
MYO3B,
CSNK1E,
CTPS1,
CTSD,
GRK3,
DDB2,
EFNA5,
ALDOA,
SNRNP200,
BRD4,
PES1,
FBXO5,
GLI1,
CECR2,
GNRHR,
GTF2H4,
SH3KBP1,
HCK,
CXXC1,
HPS1,
HSD17B4,
ICT1,
IGF2R,
FAM131C,
ITGB5,
LIMK2,
MATK,
MCL1,
MYC,
MYCN,
MYLK,
NEK2,
NQO2,
NTRK1,
WEE2,
PCBD1,
ATP5D,
REV1,
PDK1,
CDK12,
PI4KB,
POLA1,
POLH,
POLR2E,
POLR2I,
HAUS7,
PKN1,
PBK,
SULF2,
MAP2K3,
MAP2K7,
PAK6,
PSMC2,
CAMK1G,
SCYL1,
PTPN9,
RAD21,
RASGRF1,
GRK1,
SDC4,
NECAB3,
SLC1A4,
WNK1,
BMPR1A,
BNIP2,
BOK,
SULT1A2,
SUV39H1,
BTK,
TIE1,
TXK,
UBE2I,
WEE1,
YES1,
CENPO,
HECTD3,
NEIL1,
ALPK1,
RASSF7,
PTP4A2,
CAMK2D,
CAMK2G,
KIF18A,
TRRAP,
GSG2,
AIFM2,
IRS2,
CRADD,
CCNK,
PRC1
|
| 22973453 |
PLoS ONE Ronald J Hause , Kin K Leung , John L Barkinge , Mark F Ciaccio , Chih-Pin Chuu , Richard B Jones |
2012-01-01 | - |
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 20800603 |
Mutat. Res. Friederike Flachsbart , Andre Franke , Rabea Kleindorp , Amke Caliebe , Hélène Blanché , Stefan Schreiber , Almut Nebel |
2010-12-10 |
PDCD6IP,
INSL5,
CHAF1A,
HMGXB4,
SMC4,
PRG4,
COQ7,
SLC35B1,
TLR6,
GLRX3,
IQGAP2,
NEU3,
ME3,
MRPS30,
SPINK5,
DIDO1,
CHI3L1,
NUDT6,
CHIT1,
RASSF1,
BIRC8,
IL17F,
HELQ,
NLRP3,
RNF157,
SLC5A11,
GALNT15,
GSTO2,
CMA1,
GABPB2,
ADH4,
IQGAP3,
OSR1,
ADH7,
GLYCTK,
UGT3A1,
PXDNL,
CRYGB,
BNIPL,
CTSG,
KLB,
PRUNE2,
DCC,
HFM1,
CLYBL,
DLAT,
DNASE1,
DNASE1L3,
AGL,
TRDMT1,
DUSP6,
EGF,
NLRP7,
SLC5A9,
EMP1,
ENO3,
ERBB3,
ESR1,
FANCA,
FANCE,
PTK2B,
A2M,
FGL1,
HSPA4L,
NLRP1,
CARD8,
ATF6,
ACIN1,
FOXM1,
SETX,
SWAP70,
FLG,
FLT3,
MAN2B2,
KHNYN,
ARHGEF12,
SIRT5,
SIRT3,
ORC3,
PPP1R15A,
POLA2,
FRK,
FUCA1,
FUCA2,
FUT2,
GCA,
GALC,
ASF1A,
GALT,
GANC,
GAPDH,
LRIT1,
FBXO5,
GALNT8,
GBGT1,
GBE1,
GCKR,
GFRA2,
GIP
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员