| Type | Description |
|---|---|
| Definition | protection of telomeres 1B |
| Date | Results | Publications |
|---|---|---|
| 2020-05-02 12:38:00 | Tumorigenesis was inhibited in Pot1b(-/-);p53(+/+) mice due to cellular senescence. Pot1b(-/-);p53(-/-) tumors also exhibited senescence, but proliferated and metastasized with expansion of Lgr6(+) stem cells indicative of senescence-associated secretory phenotype. | 31043491 |
| 2019-04-13 11:44:00 | results establish that shelterin represses ATR with a tethered ssDNA-binding domain that excludes RPA from the 3' overhang and also reveal an unexpected effect of CST on the ability of POT1b to repress ATR | 30082315 |
| 2015-01-24 11:49:00 | demonstrated that cells expressing TIN2DeltaTPP1 instead of wild-type TIN2 phenocopy the POT1a,b knockout setting without showing additional phenotypes | 25056954 |
| 2012-09-22 10:22:00 | Study documents the combinatorial action of Apollo, POT1b, CST, and the 5' exonuclease Exo1 in postreplicative telomere end processing in mouse cells, clarifying the mechanism by which the telomeric 3' overhang is generated and modulated. | 22748632 |
| 2012-01-28 12:16:00 | Pot1b plays an essential role in hematopoietic stem cell survival. | 21948176 |
| Type | IDs |
|---|---|
| Synonymous | 2810458H16Rik |
| Gene |
UniProtKB-ID:
Q3TNS5_MOUSE,
H7BX60_MOUSE
UniprotKB:
Q3TNS5,
H7BX60
UniParc:
UPI00001EB39E,
UPI00001E3C18
EMBL:
AC154443,
AC182748,
AK165040
Ensembl:
ENSMUSG00000024174
|
| Nucleutide sequences |
EMBL-CDS:
BAE38013.1
Ensembl_TRS:
ENSMUST00000233972,
ENSMUST00000086876
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000156746,
ENSMUSP00000084089
RefSeq:
XP_006525042.1,
XP_006525043.1,
XP_036016688.1,
XP_011244947.1,
NP_082646.1,
XP_011244948.1,
XP_036016687.1,
XP_030105924.1,
NP_001361734.1,
XP_006525041.1
|
| Others |
UniRef100:
UniRef100_H7BX60,
UniRef100_Q3TNS5
UniRef90:
UniRef90_H7BX60
UniRef50:
UniRef50_H7BX60
UniGene:
Mm.177073,
Mm.448349
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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