| Type | Description |
|---|---|
| Definition | defensin alpha 1B |
| Date | Results | Publications |
|---|---|---|
| 2020-02-01 11:01:00 | our findings suggest that DEFA1B and NLRP3 gene expression levels can be used as valuable biologic markers for estimation of disease activity in NBD and as potential targets for future therapeutic trials for inflammatory disorders. | 31471397 |
| 2018-11-10 11:53:00 | Human Neutrophil Peptide 1 directly binds and neutralizes Exotoxin A of Pseudomonas aeruginosa. | 29738776 |
| 2018-10-20 10:50:00 | Inflammatory regulation of defensin alpha 1 (human neutrophil peptide 1; HNP-1) in pancreatic ductal adenocarcinoma (PDAC) tissue and cells indicates that HNP-1 may be a link between chronic inflammation and malignant transformation in the pancreas. | 29683978 |
| 2015-03-21 13:18:00 | binding of HNP1 to affected bacterial toxins caused their local unfolding, potentiated their thermal melting and precipitation, exposed new regions for proteolysis, and increased susceptibility to collisional quenchers. | 25517613 |
| 2014-10-03 14:55:00 | DEFA1B encodes an antibacterial peptide that is bacteriocidal against S. aureus, E. coli, and P. aeruginosa. | 2997278 |
| Type | IDs |
|---|---|
| Synonymous | HNP-1, HP-1, HP1 |
| Gene |
UniProtKB-ID:
DEF1_HUMAN
UniprotKB:
P59665
UniParc:
UPI0000129144
EMBL:
X52053,
L12690,
AF200455,
BC112188,
BC093791,
AF238378,
M26602,
BC069423,
M21130
Ensembl:
ENSG00000285176,
ENSG00000240247,
ENSG00000206047,
ENSG00000284983
KO:
hsa:1667,
hsa:728358
|
| Nucleutide sequences |
EMBL-CDS:
CAA36280.1,
AAH69423.1,
AAT68884.1,
AAT68875.1,
AAT68883.1,
AAA52302.1,
AAT68878.1,
AAH93791.1,
AAA52303.1,
AAT68880.1,
AAA36382.1,
AAT68879.1,
AAI12189.1
Ensembl_TRS:
ENST00000382689,
ENST00000382679,
ENST00000645146,
ENST00000644528,
ENST00000644617,
ENST00000644834,
ENST00000382692
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000493747,
ENSP00000496578,
ENSP00000496058,
ENSP00000496340,
ENSP00000372126,
ENSP00000372139,
ENSP00000372136
RefSeq:
NP_001035965.1,
NP_001289194.1
|
| Others |
UniRef100:
UniRef100_P59665
UniRef90:
UniRef90_P59665
UniRef50:
UniRef50_P59665
UniGene:
Hs.380781
CCDS:
CCDS34797.1,
CCDS43691.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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