| Type | Description |
|---|---|
| Definition | R-spondin 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 12:33:00 | RSPO3 was found to be highly elevated in the active lesions of fibrotic tissues in mouse models of fibrosis. | 32160239 |
| 2020-01-18 12:12:00 | Results show that R-spondin3 protein (Rspo3) is essential for epithelial repair via induction of of Wnt signaling in differentiated cells. | 31554819 |
| 2019-11-02 11:45:00 | Study found that R-Spo3 was the major R-Spo family member produced in the intestine and it was predominantly produced by CD45-CD90+CD31+ lymphatic endothelial cells (LECs) in the lamina propria of the intestinal mucosa. LECs were significantly reduced in number, and their R-Spo3 production was impaired in intestinal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. | 30013036 |
| 2019-09-28 11:04:00 | RSPO3 knockdown in basal-like mouse mammary tumor cells reduced canonical Wnt signaling, epithelial-to-mesenchymal transition-like features, migration capacity, and tumor formation in vivo Conversely, RSPO3 overexpression, which was associated with some LGR and RUNX factors, highly correlated with the basal-like subtype among patients with breast cancer | 29748375 |
| 2019-01-05 12:13:00 | Rspo2 and Rspo3 fusion events are sufficient to initiate hyperplasia and tumour development. | 28695896 |
| Type | IDs |
|---|---|
| Synonymous | 2810459H04Rik, AW742308, Cristin1, Thsd2 |
| Gene |
UniProtKB-ID:
RSPO3_MOUSE
UniprotKB:
Q2TJ95
UniParc:
UPI0000565183
EMBL:
AY864332,
AK076308,
AK013366,
AB055811,
BC145929,
BC145931,
BC103794
Ensembl:
ENSMUSG00000019880
KO:
mmu:72780
|
| Nucleutide sequences |
EMBL-CDS:
AAI45930.1,
AAI45932.1,
AAX57441.1,
BAC36296.1,
BAB28811.1,
AAI03795.1,
BAC41353.1
Ensembl_TRS:
ENSMUST00000092623
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000090287
RefSeq:
NP_082627.3
|
| Others |
UniRef100:
UniRef100_Q2TJ95
UniRef90:
UniRef90_Q2TJ95
UniRef50:
UniRef50_Q2TJ95
UniGene:
Mm.45191
CCDS:
CCDS23761.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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