| Type | Description |
|---|---|
| Definition | receptor-interacting serine-threonine kinase 4 |
| Date | Results | Publications |
|---|---|---|
| 2019-11-30 10:57:00 | results explain how RIPK4 and IRF6 function to ensure the integrity of the epidermis and provide mechanistic insights into why developmental syndromes that are characterized by orofacial, skin and genital abnormalities result when this axis goes awry | 31578523 |
| 2019-05-25 11:51:00 | Study of keratinocyte-specific RIPK4 knockout (KO) mice found that RIPK4 in keratinocytes is essential for the establishment of a functional inside-out skin barrier but is not required for the formation of a functional outside-in barrier during development. In addition, we show that epithelial fusions in RIPK4 full KO mice are E-cadherin dependent. | 29317263 |
| 2019-02-23 10:39:00 | Study presents the first crystal structure of Ripk4 and uses a structure- and biochemistry-guided approach to demonstrate that the Ripk4 homodimer is essential for catalytic activity. | 29706531 |
| 2018-11-03 11:53:00 | We further define the interactions of keratinocyte PKK with TP63 and NF-kappaB signaling, highlighting the importance of this protein as a tumor suppressor in skin squamous cell carcinoma development. | 29186361 |
| 2018-01-27 10:27:00 | this work uncovers a critical role of PKK in lupus development | 28274793 |
| Type | IDs |
|---|---|
| Synonymous | 2310069J12Rik, AI552420, ANKK2, Ankrd3, DIk, PKK, RIP4 |
| Gene |
UniProtKB-ID:
RIPK4_MOUSE
UniprotKB:
Q9ERK0
UniParc:
UPI00000216A7
EMBL:
AK145203,
BC057871,
AF302127
Ensembl:
ENSMUSG00000005251
KO:
mmu:72388
|
| Nucleutide sequences |
EMBL-CDS:
AAG30871.2,
BAE26294.1,
AAH57871.1
Ensembl_TRS:
ENSMUST00000019386
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000019386
RefSeq:
XP_011244456.1,
NP_076152.2
|
| Others |
UniRef100:
UniRef100_Q9ERK0
UniRef90:
UniRef90_Q9ERK0
UniRef50:
UniRef50_P57078
UniGene:
Mm.35290
CCDS:
CCDS28360.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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