| Type | Description |
|---|---|
| Definition | transient receptor potential cation channel subfamily C member 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-09-26 13:01:00 | Differential PI(4,5)P2 sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels. | 30755645 |
| 2019-11-02 11:32:00 | Study reports a novel mechanism of self-limiting activation of TRPC1/4 and TRPC1/5 channels by G protein-coupled receptor stimulation. Galphaq protein directly interacts with either TRPC4 or TRPC5 of the heterotetrameric channels to permit activation. Simultaneously, Galphaq-coupled PLCbeta activation leads to the breakdown of PI(4,5)P2, which inhibits activity of TRPC1/4 and 1/5 channels. | 30108272 |
| 2019-09-14 11:20:00 | We found that the inhibitory Galphai3 protein selectively bound to the G-protein-binding domain on the C-terminus of PC1. The dissociation of Galphai3 upon cleavage of PC1 increased TRPC4 activity. | 29472562 |
| 2018-05-12 11:36:00 | Our results suggest that OGR1-dependent increases in TRPC4 expression may favor formation of highly Ca(2+) -permeable TRPC4-containing channels that promote transformed granule cell migration. Increased motility of cancer cells is a prerequisite for cancer invasion and metastasis, and our findings may point towards a key role for TRPC4 in progression of certain types of medullablastoma. | 28627017 |
| 2018-03-31 11:17:00 | Protein levels of TRPC4 were elevated in FCD II and tuberous sclerosis complex cortical samples compared to those of control samples. | 28455787 |
| Type | IDs |
|---|---|
| Synonymous | HTRP-4, HTRP4, TRP4 |
| Gene |
UniProtKB-ID:
TRPC4_HUMAN
UniprotKB:
Q9UBN4
UniParc:
UPI000006E5BE,
UPI000006E8B2,
UPI000002B623,
UPI00000715A3,
UPI000002B622,
UPI000002B621,
UPI00001374B2
EMBL:
AF063823,
AF421362,
AF421361,
AF421359,
AF421360,
AF063822,
AL354802,
AL138679,
AF063824,
AF421358,
BC104725,
U40983,
AF063825,
AF175406,
CH471075
Ensembl:
ENSG00000133107
KO:
hsa:7223
|
| Nucleutide sequences |
EMBL-CDS:
AAF22927.1,
AAL24549.1,
AAL24551.1,
EAX08598.1,
AAI04726.1,
AAF22928.1,
EAX08595.1,
AAD51736.1,
EAX08600.1,
EAX08601.1,
EAX08597.1,
AAL24553.1,
EAX08596.1,
AAC50630.1,
AAL24550.1,
AAL24552.1,
AAF22929.1,
AAF22930.1
Ensembl_TRS:
ENST00000358477,
ENST00000379705,
ENST00000355779,
ENST00000379679,
ENST00000379673,
ENST00000338947,
ENST00000625583,
ENST00000488717
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000368995,
ENSP00000369027,
ENSP00000486109,
ENSP00000369001,
ENSP00000435969,
ENSP00000351264,
ENSP00000348025,
ENSP00000342580
RefSeq:
NP_001341735.1,
XP_011533508.1,
NP_003297.1,
NP_001129430.1,
NP_001129427.1,
XP_016876212.1,
NP_057263.1,
NP_001129429.1,
NP_001358984.1,
NP_001129428.1,
NP_001341728.1
|
| Others |
UniRef100:
UniRef100_Q9UBN4
UniRef90:
UniRef90_Q9UBN4
UniRef50:
UniRef50_Q9UBN4
UniGene:
Hs.262960
CCDS:
CCDS45039.1,
CCDS45037.1,
CCDS45038.1,
CCDS45036.1,
CCDS9365.1,
CCDS45035.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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