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72169 Trim29

72169

Trim29

tripartite motif-containing 29

protein-coding

Mus musculus

基因描述

Type Description
Definition tripartite motif-containing 29

研究结论

Date Results Publications
2020-04-11 10:57:00 results identify TRIM29 as a negative regulator of NK cell functions 31270148
2019-09-07 11:43:00 deletion of the Atdc (Trim29) gene, whose human homolog is upregulated in the majority of pancreatic adenocarcinoma, prevents pancreatic adenocarcinoma development in the context of oncogenic KRAS; findings show ATDC (Trim29) promotes acinar-ductal metaplasia progression to pancreatic intraepithelial neoplasia through activation of beta-catenin signaling and subsequent SOX9 up-regulation 31048544
2019-06-01 10:40:00 TRIM29 regulates negatively the host innate immune response to RNA virus, which could be employed by RNA viruses for viral pathogenesis. 29769269
2018-03-10 11:15:00 Knockdown of tripartite motif-containing 29 protein (TRIM29) enhanced the production of type I interferon in human and mouse dendritic cells by up to fourfold in response to intracellular herpes simplex virus. 29038422
2017-06-03 11:38:00 this study shows that deletion of TRIM29 enhanced macrophage production of type I interferons and protected mice from infection with influenza virus, while challenge of Trim29-/- mice with Haemophilus influenzae resulted in lethal lung inflammation due to massive production of proinflammatory cytokines by macrophages 27695001

名称对应

Type IDs
Synonymous 1110047J21Rik, 2810431N19Rik, 4732461M22Rik, AI119726
Gene
UniProtKB-ID: TRI29_MOUSE
UniprotKB: Q8R2Q0
UniParc: UPI00000E5CDB
EMBL: AK013219, AK028448, BC027353, BC006699, AF230390
Ensembl: ENSMUSG00000032013
KO: mmu:72169
Nucleutide sequences
EMBL-CDS: BAC25956.1, AAG50169.1, BAB28721.1, AAH27353.1, AAH06699.1
Ensembl_TRS: ENSMUST00000034511
Protein sequencees
Ensembl_PRO: ENSMUSP00000034511
RefSeq: NP_076144.2, XP_006510680.1, XP_006510679.1
Others
UniRef100: UniRef100_Q8R2Q0
UniRef90: UniRef90_Q8R2Q0
UniRef50: UniRef50_Q14134
UniGene: Mm.273277
CCDS: CCDS52775.1

全选

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