| Type | Description |
|---|---|
| Definition | protein phosphatase 2, regulatory subunit B, alpha |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 12:35:00 | Proteomics identified the PP2A regulatory subunit B55alpha as the factor recruiting PP2A to PDE4D5. The B55alpha-PP2A complex localized to adhesions and directly dephosphorylated PDE4D5. | 31408443 |
| 2017-06-10 10:12:00 | Data suggest IGT10 mice, diabetes type 2 model, exhibit 2 genetic defects: haploinsufficiency (heterozygosity for null allele) of insulin receptor (Insr); splice-site mutation in protein phosphatase 2 regulatory subunit B alpha (Ppp2r2a). Inheritance of either allele results in insulin resistance but not overt diabetes. Double heterozygosity leads to insulin resistance and diabetes type 2 without increase in body weight. | 26868295 |
| 2016-04-30 11:57:00 | Concurrent mTORC1 inactivation and PP2A-B55alpha stimulation fuel ULK1-dependent autophagy. | 26310906 |
| 2014-10-25 10:59:00 | FBXL16 negatively regulates the activity of B55alpha-PP2A to modulate the genesis of FLK1+ progenitor cells. | 24390425 |
| 2014-10-18 11:08:00 | Ppp2r2a is required for Connexin-43 dephosphorlyation during epidermal barrier acquisition | 24433183 |
| Type | IDs |
|---|---|
| Synonymous | 2410004D02Rik, mKIAA1541 |
| Gene |
UniProtKB-ID:
2ABA_MOUSE,
Q9CWU3_MOUSE,
Q3TT94_MOUSE
UniprotKB:
Q6P1F6,
Q9CWU3,
Q3TT94
UniParc:
UPI0000027252,
UPI000000D997
EMBL:
CT030233,
AK161507,
BC080692,
AK010380,
AK167189,
AK161704,
BC065100,
AC165148
Ensembl:
ENSMUSG00000022052
KO:
mmu:71978
|
| Nucleutide sequences |
EMBL-CDS:
AAH65100.1,
AAH80692.1,
BAB26898.1,
BAE39320.1,
BAE36431.1,
BAE36540.1
Ensembl_TRS:
ENSMUST00000089230,
ENSMUST00000225380
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000086640,
ENSMUSP00000153191
RefSeq:
NP_001192117.1,
NP_001346962.1,
NP_082308.1,
NP_001346963.1
|
| Others |
UniRef100:
UniRef100_Q9CWU3,
UniRef100_P63151
UniRef90:
UniRef90_Q9CWU3,
UniRef90_P63151
UniRef50:
UniRef50_V8NND4,
UniRef50_P63151
UniGene:
Mm.273997
CCDS:
CCDS56967.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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