| Type | Description |
|---|---|
| Definition | transmembrane protein 106B |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:40:00 | The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons. | 32160553 |
| 2021-01-02 12:51:00 | A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination. | 32572497 |
| 2019-07-20 12:52:00 | Data show that the frontotemporal dementia (FTD)-causing C-terminal truncation of CHMP2B results in dendritic endolysosomal trafficking defects. Strikingly, we found that this trafficking defect could be rescued by the knockdown of the FTD risk factor Tmem106b. | 30496365 |
| 2019-06-01 10:12:00 | This work suggests that the protective TMEM106B haplotype may exert its effect in expansion carriers by counteracting lysosomal dysfunction resulting from a loss of C9ORF72. | 29855382 |
| 2018-12-22 11:31:00 | TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins. | 30013069 |
| Type | IDs |
|---|---|
| Synonymous | 2310036D22Rik, 5830455K21Rik, 6430519M21Rik, AI428776, AI661344 |
| Gene |
UniProtKB-ID:
T106B_MOUSE
UniprotKB:
Q80X71
UniParc:
UPI000002323E
EMBL:
BC050246,
AK009646
Ensembl:
ENSMUSG00000029571
KO:
mmu:71900
|
| Nucleutide sequences |
EMBL-CDS:
BAB26411.1,
AAH50246.1
Ensembl_TRS:
ENSMUST00000031556
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000031556
RefSeq:
NP_082268.2,
XP_006505232.1
|
| Others |
UniRef100:
UniRef100_Q80X71
UniRef90:
UniRef90_Q80X71
UniRef50:
UniRef50_Q9NUM4
UniGene:
Mm.27742
CCDS:
CCDS19914.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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