Rgs12 - regulator of G-protein signaling 12-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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71729 Rgs12

基因描述

Type	Description
Definition	regulator of G-protein signaling 12

研究结论

Date	Results	Publications
2020-07-18 10:54:00	findings reveal that Rgs12 is an important regulator during osteogenesis and highlight Rgs12 as a potential therapeutic target for bone disorders.	30489658
2020-03-21 11:37:00	Findings highlight a role for RGS12 as a novel, differential regulator of both G protein-dependent and -independent signaling downstream of KOR activation.	31141817
2020-03-07 12:15:00	when mice lacking skeletal muscle expression of Rgs12 were cross-bred with mdx mice (a model of human Duchenne muscular dystrophy), no increase in muscle degeneration was observed over time	31408461
2020-02-15 12:59:00	This study identified a novel role of Rgs12 in regulating Nrf2, thereby controlling cellular redox state and osteoclast differentiation.	31490121
2017-07-22 12:57:00	RGS12 protein plays an important role in the pathogenesis of cardiac hypertrophy and could be a novel target for molecular therapy.	27091895

名称对应

Type	IDs
Synonymous	1200016K18Rik, 4632412M04Rik, AI481290, E130309H11
Gene	UniProtKB-ID: RGS12_MOUSE, Q9D677_MOUSE, Q3TTW9_MOUSE, D3Z0G5_MOUSE, Q8BPL6_MOUSE, E9Q1K7_MOUSE, E9Q652_MOUSE UniprotKB: Q8CGE9, Q9D677, Q3TTW9, D3Z0G5, Q8BPL6, E9Q1K7, E9Q652 UniParc: UPI00000EB072, UPI00015AA25F, UPI00005B1CEC, UPI000021791F, UPI00001C335A, UPI00015AA262, UPI00000E84C9 EMBL: AK014569, AK053804, AK161129, BC040396, AC126447, AC133204 Ensembl: ENSMUSG00000029101 KO: mmu:71729
Nucleutide sequences	EMBL-CDS: AAH40396.1, BAB29434.1, BAE36205.1, BAC35534.1 Ensembl_TRS: ENSMUST00000030984, ENSMUST00000114280, ENSMUST00000114285, ENSMUST00000114281, ENSMUST00000087684
Protein sequencees	Ensembl_PRO: ENSMUSP00000030984, ENSMUSP00000109919, ENSMUSP00000109924, ENSMUSP00000109920, ENSMUSP00000084970 RefSeq: XP_006504183.1, XP_006504186.1, NP_001156984.1, XP_030110673.1, XP_006504184.1, NP_775578.2, XP_006504188.1, XP_036021387.1, XP_006504187.1, XP_006504189.1, XP_030110672.1, XP_006504185.1
Others	UniRef100: UniRef100_E9Q652, UniRef100_E9Q1K7, UniRef100_D3Z0G5, UniRef100_Q9D677, UniRef100_Q8BPL6, UniRef100_Q8CGE9, UniRef100_Q3TTW9 UniRef90: UniRef90_Q8BPL6, UniRef90_Q8CGE9, UniRef90_O08774-2, UniRef90_Q3TTW9 UniRef50: UniRef50_O08774-2, UniRef50_A0A3Q1MTC8, UniRef50_O08774, UniRef50_A0A673I0B7 UniGene: Mm.196208 CCDS: CCDS19222.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
32325033	BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Cell Syst Reza Pourhaghighi , Peter E A Ash , Sadhna Phanse , Florian Goebels , Lucas Z M Hu , Siwei Chen , Yingying Zhang , Shayne D Wierbowski , Samantha Boudeau , Mohamed T Moutaoufik , Ramy H Malty , Edyta Malolepsza , Kalliopi Tsafou , Aparna Nathan , Graham Cromar , Hongbo Guo , Ali Al Abdullatif , Daniel J Apicco , Lindsay A Becker , Aaron D Gitler , Stefan M Pulst , Ahmed Youssef , Ryan Hekman , Pierre C Havugimana , Carl A White , Benjamin C Blum , Antonia Ratti , Camron D Bryant , John Parkinson , Kasper Lage , Mohan Babu , Haiyuan Yu , Gary D Bader , Benjamin Wolozin , Andrew Emili	2020-04-22	-
31490121	Regulator of G protein signaling 12 enhances osteoclastogenesis by suppressing Nrf2-dependent antioxidant proteins to promote the generation of reactive oxygen species. Elife Andrew Ying Hui Ng , Ziqing Li , Megan M Jones , Shuting Yang , Chunyi Li , Chuanyun Fu , Chengjian Tu , Merry Jo Oursler , Jun Qu , Shuying Yang	2019-09-06	-
31141817	Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior. Neuropsychopharmacology Joshua D Gross , Shane W Kaski , Karl T Schmidt , Elizabeth S Cogan , Kristen M Boyt , Kim Wix , Adam B Schroer , Zoe A McElligott , David P Siderovski , Vincent Setola	2019-09-01	-
30489658	Regulator of G Protein Signaling Protein 12 (Rgs12) Controls Mouse Osteoblast Differentiation via Calcium Channel/Oscillation and GÎ±i-ERK Signaling. J Bone Miner Res Ziqing Li , Tongjun Liu , Alyssa Gilmore , NÃ©stor MÃ¡s GÃ³mez , Chuanyun Fu , Jormay Lim , Shuting Yang , Claire H Mitchell , Yi-Ping Li , Merry J Oursler , Shuying Yang	2019-04-01	-
31408461	A role for Regulator of G protein Signaling-12 (RGS12) in the balance between myoblast proliferation and differentiation. PLoS ONE Adam B Schroer , Junaith S Mohamed , Melinda D Willard , Vincent Setola , Emily Oestreich , David P Siderovski	2019-01-01	-
29364035	Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants. J. Psychopharmacol. (Oxford) Joshua D Gross , Shane W Kaski , Adam B Schroer , Kimberley A Wix , David P Siderovski , Vincent Setola	2018-02-01	-
27091895	Pivotal Role of Regulator of G-protein Signaling 12 in Pathological Cardiac Hypertrophy. Hypertension Jia Huang , Lijuan Chen , Yuyu Yao , Chengchun Tang , Jiandong Ding , Cong Fu , Hongliang Li , Genshan Ma	2016-06-01	-
25909889	Regulators of G protein signaling 12 promotes osteoclastogenesis in bone remodeling and pathological bone loss. Cell Death Differ. X Yuan , J Cao , T Liu , Y-P Li , F Scannapieco , X He , M J Oursler , X Zhang , J Vacher , C Li , D Olson , S Yang	2015-12-01	-
24154525	Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development Jeremy A Miller , Jason Nathanson , Daniel Franjic , Sungbo Shim , Rachel A Dalley , Sheila Shapouri , Kimberly A Smith , Susan M Sunkin , Amy Bernard , Jeffrey L Bennett , Chang-Kyu Lee , Michael J Hawrylycz , Allan R Jones , David G Amaral , Nenad Å estan , Fred H Gage , Ed S Lein	2013-11-01	Rpp25, Gldc, Rhoq, Psat1, Tm6sf1, Slc14a1, Rimklb, Nusap1, Mybpc1, Npy, Bmp3, Adgrv1, Dlx1as, Acadl, Laptm4b, Pawr, Adra1a, Alcam, Aldoc, Necab2, Ank1, Apoe, Nr2f2, Aqp4, Rnd2, Arnt2, Bcan, Bcat1, Fabp7, Zfp36l1, C1qc, Calb2, Capn2, Car2, Cbln2, Cbs, Ccnd2, Cd24a, Entpd2, Cd63, Cd81, Cd9, Cdh11, Cdh5, Cit, Ckb, Cldn5, Clu, Cnp, Cnr1, Col19a1, Col9a3, Cort, Cox6a2, Cplx1, Hapln1, Cryab, Csrp1, Cst3, Ctsd, Ctsl, Ctss, Cux2, Dbi, Dcx, Asap1, Dio2, Dlx1, Cdk2ap1, Ect2, Egfr, Eps8, Erbb4, Eya4, Elmo1, Fasn, Fgf12, Fgfr1, Gaa, Gabrg3, Gad1, Gad2, Gap43, Gfap, Gpr83, Gja1, Gjd2, Glul, Glrb, Gnai1, Gnas, Got1, Adgrg1, Cdca3, Gria4, Grik1, Grpr, Hbb-b1, Hbb-b2
23349096	Mx1-cre mediated Rgs12 conditional knockout mice exhibit increased bone mass phenotype. Genesis Shuying Yang , Yi-Ping Li , Tongjun Liu , Xiaoning He , Xue Yuan , Chunyi Li , Jay Cao , Yunjung Kim	2013-03-01	-

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