Telo2 - telomere maintenance 2-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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71718 Telo2

基因描述

Type	Description
Definition	telomere maintenance 2

研究结论

Date	Results	Publications
2019-10-12 11:05:00	Upregulating Tel2 expression increases mTOR-mediated cardiomyocyte survival and targeting Tel2 could be another therapeutic strategy against ischemic heart disease	31323273
2014-05-31 12:25:00	IP7, formed by IP6K2, binds CK2 to enhance its phosphorylation of the Tti1/Tel2 complex, thereby stabilizing DNA-PKcs and ATM. This process stimulates p53 phosphorylation at serine 15 to activate the cell death program.	24657168
2011-01-01 11:14:00	The CK2 phospho-dependent interaction between TEL2 and the R2TP complex affects phosphatidylinositol 3-kinase-related kinase functions and is essential for mTOR and SMG1 stability in vivo.	20864032
2010-01-21 00:00:00	Identify Tel2 as a highly conserved regulator of the stability of PI3K-related protein kinases.	18160036

名称对应

Type	IDs
Synonymous	1200003M09Rik, AI415602, Tel2, mKIAA0683
Gene	UniProtKB-ID: TELO2_MOUSE UniprotKB: Q9DC40 UniParc: UPI000002227B, UPI00000EB283 EMBL: AK146963, AK045321, AK004582, BC011077, AK028658, AK143827, AK154727, AY491413 Ensembl: ENSMUSG00000024170 KO: mmu:71718
Nucleutide sequences	EMBL-CDS: AAH11077.1, BAC32309.1, BAE25556.1, BAB23388.1, BAE32791.1, AAS21644.1, BAE27569.1, BAC26051.1 Ensembl_TRS: ENSMUST00000115181, ENSMUST00000024987
Protein sequencees	Ensembl_PRO: ENSMUSP00000110835, ENSMUSP00000024987 RefSeq: NP_082156.2, NP_001157133.1, XP_011244921.1, XP_036016682.1, XP_036016681.1, XP_011244920.1
Others	UniRef100: UniRef100_Q9DC40 UniRef90: UniRef90_Q9DC40 UniRef50: UniRef50_Q9Y4R8 UniGene: Mm.288702 CCDS: CCDS28507.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
31323273	The effects of Tel2 on cardiomyocyte survival. Life Sci Naaiko Yorichika , Yuichi Baba , Briana K Shimada , Manoj Thakore , Sharon M Wong , Motoi Kobayashi , Jason K Higa , Takashi Matsui	2019-09-01	-
27880917	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. Cell Rep Nicole St-Denis , Gagan D Gupta , Zhen Yuan Lin , Beatriz Gonzalez-Badillo , Amanda O Veri , James D R Knight , Dushyandi Rajendran , Amber L Couzens , Ko W Currie , Johnny M Tkach , Sally W T Cheung , Laurence Pelletier , Anne-Claude Gingras	2016-11-22	-
24794838	Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1. Structure Mohinder Pal , Marc Morgan , Sarah E L Phelps , S Mark Roe , Sarah Parry-Morris , Jessica A Downs , Sigrun Polier , Laurence H Pearl , Chrisostomos Prodromou	2014-06-10	-
24657168	Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2. Mol Cell Feng Rao , Jiyoung Cha , Jing Xu , Risheng Xu , M Scott Vandiver , Richa Tyagi , Robert Tokhunts , Michael A Koldobskiy , Chenglai Fu , Roxanne Barrow , Mingxuan Wu , Dorothea Fiedler , James C Barrow , Solomon H Snyder	2014-04-10	-
22673621	Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Am J Physiol Cell Physiol Sudarsanareddy Lokireddy , Isuru Wijerupage Wijesoma , Siu Kwan Sze , Craig McFarlane , Ravi Kambadur , Mridula Sharma	2012-09-01	-
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
20864032	CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Mol Cell Zuzana HorejsÃ , Hiroyuki Takai , Carrie A Adelman , Spencer J Collis , Helen Flynn , Sarah Maslen , J Mark Skehel , Titia de Lange , Simon J Boulton	2010-09-24	-
20801936	Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev. Hiroyuki Takai , Yihu Xie , Titia de Lange , Nikola P Pavletich	2010-09-15	-
18160036	Tel2 regulates the stability of PI3K-related protein kinases. Cell Hiroyuki Takai , Richard C Wang , Kaori K Takai , Haijuan Yang , Titia de Lange	2007-12-28	Atm, Gt(ROSA)26Sor, Trp53, Mtor, Telo2, Mtor, SMG1, MTOR, ATM, ATR, PRKDC, TERF1, TRRAP, TELO2
16141072	The transcriptional landscape of the mammalian genome. Science P Carninci , T Kasukawa , S Katayama , J Gough , M C Frith , N Maeda , R Oyama , T Ravasi , B Lenhard , C Wells , R Kodzius , K Shimokawa , V B Bajic , S E Brenner , S Batalov , A R R Forrest , M Zavolan , M J Davis , L G Wilming , V Aidinis , J E Allen , A Ambesi-Impiombato , R Apweiler , R N Aturaliya , T L Bailey , M Bansal , L Baxter , K W Beisel , T Bersano , H Bono , A M Chalk , K P Chiu , V Choudhary , A Christoffels , D R Clutterbuck , M L Crowe , E Dalla , B P Dalrymple , B de Bono , G Della Gatta , D di Bernardo , T Down , P Engstrom , M Fagiolini , G Faulkner , C F Fletcher , T Fukushima , M Furuno , S Futaki , M Gariboldi , P Georgii-Hemming , T R Gingeras , T Gojobori , R E Green , S Gustincich , M Harbers , Y Hayashi , T K Hensch , N Hirokawa , D Hill , L Huminiecki , M Iacono , K Ikeo , A Iwama , T Ishikawa , M Jakt , A Kanapin , M Katoh , Y Kawasawa , J Kelso , H Kitamura , H Kitano , G Kollias , S P T Krishnan , A Kruger , S K Kummerfeld , I V Kurochkin , L F Lareau , D Lazarevic , L Lipovich , J Liu , S Liuni , S McWilliam , M Madan Babu , M Madera , L Marchionni , H Matsuda , S Matsuzawa , H Miki , F Mignone , S Miyake , K Morris , S Mottagui-Tabar , N Mulder , N Nakano , H Nakauchi , P Ng , R Nilsson , S Nishiguchi , S Nishikawa , F Nori , O Ohara , Y Okazaki , V Orlando , K C Pang , W J Pavan , G Pavesi , G Pesole , N Petrovsky , S Piazza , J Reed , J F Reid , B Z Ring , M Ringwald , B Rost , Y Ruan , S L Salzberg , A Sandelin , C Schneider , C SchÃ¶nbach , K Sekiguchi , C A M Semple , S Seno , L Sessa , Y Sheng , Y Shibata , H Shimada , K Shimada , D Silva , B Sinclair , S Sperling , E Stupka , K Sugiura , R Sultana , Y Takenaka , K Taki , K Tammoja , S L Tan , S Tang , M S Taylor , J Tegner , S A Teichmann , H R Ueda , E van Nimwegen , R Verardo , C L Wei , K Yagi , H Yamanishi , E Zabarovsky , S Zhu , A Zimmer , W Hide , C Bult , S M Grimmond , R D Teasdale , E T Liu , V Brusic , J Quackenbush , C Wahlestedt , J S Mattick , D A Hume , C Kai , D Sasaki , Y Tomaru , S Fukuda , M Kanamori-Katayama , M Suzuki , J Aoki , T Arakawa , J Iida , K Imamura , M Itoh , T Kato , H Kawaji , N Kawagashira , T Kawashima , M Kojima , S Kondo , H Konno , K Nakano , N Ninomiya , T Nishio , M Okada , C Plessy , K Shibata , T Shiraki , S Suzuki , M Tagami , K Waki , A Watahiki , Y Okamura-Oho , H Suzuki , J Kawai , Y Hayashizaki , FANTOM Consortium , RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)	2005-09-02	-

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