| Type | Description |
|---|---|
| Definition | optineurin |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:29:00 | Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease. | 31076632 |
| 2021-02-27 13:48:00 | ALS-Related Mutant SOD1 Aggregates Interfere with Mitophagy by Sequestering the Autophagy Receptor Optineurin. | 33065963 |
| 2020-12-12 13:26:00 | Optineurin regulates osteoblastogenesis through | 32171527 |
| 2020-05-16 11:07:00 | In murine renal tubule epithelial cells the levels of OPTN mRNA and protein decreased significantly after stimulation by a high glucose treatment. RTECs overexpressing OPTN showed significantly lower levels of NLRP3 expression, cleavage of caspase-1 and IL-1beta, and release of IL-1 beta and IL-18. OPTN gene silencing significantly enhanced production of mitochondrial reactive oxygen species after high glucose. | 30571313 |
| 2019-06-15 10:31:00 | OPTN may be a potential antisenescence factor in diabetic nephropathy. | 29367621 |
| Type | IDs |
|---|---|
| Synonymous | 4930441O07Rik, FIP2, HYPL, NRP |
| Gene |
UniProtKB-ID:
OPTN_MOUSE
UniprotKB:
Q8K3K8
UniParc:
UPI0000028A18
EMBL:
AY340632,
AY340634,
AL928662,
AY340631,
AY340630,
AY340623,
AY071834,
AY340626,
AY340627,
AY340629,
AY340625,
AY340624,
AY340635,
AY340628,
AY340633,
BC061185
Ensembl:
ENSMUSG00000026672
KO:
mmu:71648
|
| Nucleutide sequences |
EMBL-CDS:
AAL61853.1,
AAQ21118.1,
AAH61185.1
Ensembl_TRS:
ENSMUST00000027986,
ENSMUST00000114996
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000027986,
ENSMUSP00000110648
RefSeq:
XP_011237289.1,
XP_006497611.1,
NP_001343416.1,
XP_006497610.1,
XP_011237290.1,
NP_862896.1,
XP_030107949.1
|
| Others |
UniRef100:
UniRef100_Q8K3K8
UniRef90:
UniRef90_Q8K3K8
UniRef50:
UniRef50_Q96CV9
UniGene:
Mm.116942
CCDS:
CCDS15663.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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