| Type | Description |
|---|---|
| Definition | complement C1s |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:24:00 | Two Different Missense C1S Mutations, Associated to Periodontal Ehlers-Danlos Syndrome, Lead to Identical Molecular Outcomes. | 31921203 |
| 2018-05-12 10:18:00 | The serine protease domains of C1r and C1s are at the periphery of the C1r2s2 tetramer both when alone or within the nonactivated C1 complex. The C1 complex adopts a conformation incompatible with intramolecular activation of C1. Instead, intermolecular proteolytic activation between neighboring C1 complexes bound to a complement-activating surface occurs. Many structurally unrelated molecular patterns can activate C1. | 28104818 |
| 2017-05-20 12:27:00 | Periodontal Ehlers-Danlos Syndrome in at least the great majority of cases results from specific classes of heterozygous mutations in C1R and C1S. | 27745832 |
| 2015-12-05 10:26:00 | C1q exists as the C1 complex (C1qC1r2C1s2), and C1q binding to ligands activates the C1r/C1s proteases. Incubation of nucleoli with C1 caused degradation of the nucleolar proteins nucleolin and nucleophosmin 1. T | 26231209 |
| 2014-09-06 12:19:00 | TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins. | 24695853 |
| Type | IDs |
|---|---|
| Synonymous | EDSPD2 |
| Gene |
UniProtKB-ID:
C1S_HUMAN,
F8WCZ6_HUMAN
UniprotKB:
P09871,
F8WCZ6
UniParc:
UPI000022932D,
UPI0000126BF6
EMBL:
J04080,
AB009076,
BC056903,
CH471116,
X06596,
M18767,
AC006512
Ensembl:
ENSG00000182326
KO:
hsa:716
|
| Nucleutide sequences |
EMBL-CDS:
AAA51852.1,
EAW88689.1,
CAA29817.1,
AAH56903.1,
BAA86864.1,
EAW88690.1,
AAA51853.1
Ensembl_TRS:
ENST00000328916,
ENST00000406697,
ENST00000360817,
ENST00000402681
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000385035,
ENSP00000354057,
ENSP00000328173,
ENSP00000384171
RefSeq:
NP_001725.1,
XP_005253817.1,
NP_001333779.1,
NP_958850.1
|
| Others |
UniRef100:
UniRef100_P09871
UniRef90:
UniRef90_P09871
UniRef50:
UniRef50_P09871
UniGene:
Hs.458355
CCDS:
CCDS31735.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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