| Type | Description |
|---|---|
| Definition | polycomb group ring finger 6 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:54:00 | The polycomb group protein PCGF6 mediates germline gene silencing by recruiting histone-modifying proteins to target gene promoters. | 32482889 |
| 2020-05-16 12:07:00 | The authors findings highlight a novel mechanism of Pcgf6 protein in regulating stem cell pluripotency: PCGF6 is recruited to a subset of the super-enhancer (SE) regions upstream of cell cycle-associated genes by Oct4 (Octamer and increased their expression, also, PCGF6 activates cell cycle genes by regulating SE-promoter interactions via 3D chromatin. | 31041782 |
| 2018-04-07 11:56:00 | Pcgf6 acts as a master regulator to maintain embryonic stem cell identity. | 27247273 |
| 2018-01-06 11:22:00 | Conditional ablation of Pcgf6 in embryonic stem cells leads to robust de-repression of germ cell-related genes, in turn affecting cell growth and viability. | 28304275 |
| 2017-11-18 10:48:00 | The results identify two key regulators, PCGF6 and JARID1c that temper dendritic cells (DC) activation and implicate active transcriptional silencing via histone demethylation as a previously unappreciated mechanism for regulating DC activation and quiescence. | 27498878 |
| Type | IDs |
|---|---|
| Synonymous | 4933407A11Rik, AI604840, MBLR, Rnf134 |
| Gene |
UniProtKB-ID:
PCGF6_MOUSE
UniprotKB:
Q99NA9
UniParc:
UPI000002250B
EMBL:
AB047007,
BC016195,
BC089460
Ensembl:
ENSMUSG00000025050
KO:
mmu:71041
|
| Nucleutide sequences |
EMBL-CDS:
AAH89460.1,
BAB40780.1,
AAH16195.1
Ensembl_TRS:
ENSMUST00000026032
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000026032
RefSeq:
XP_006527401.1,
XP_030106935.1,
NP_001347561.1,
XP_036017580.1,
NP_081930.1
|
| Others |
UniRef100:
UniRef100_Q99NA9
UniRef90:
UniRef90_Q99NA9
UniRef50:
UniRef50_Q99NA9
UniGene:
Mm.35413
CCDS:
CCDS29885.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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