| Type | Description |
|---|---|
| Definition | tyrosine kinase with immunoglobulin like and EGF like domains 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-27 13:47:00 | TIE1 as a for Lymphatic Malformations with or without Lymphedema. | 32947856 |
| 2020-03-28 10:34:00 | Results found deregulated expression of TIE1 in non-small cell lung cancer (NSCLC) tissues to be associated with poor clinical outcome. | 30806032 |
| 2020-02-15 10:51:00 | Study in metastatic breast cancer patients treated with a taxane-bevacizumab combination chemotherapy revealed that overall and progression-free survival was significantly shorter in patients with a high baseline Tie1 level demonstrating the prognostic value of baseline Tie1 plasma concentration in patients with metastatic breast cancer. | 31340773 |
| 2019-07-20 10:15:00 | Tie1 has regulatory functions in angiogenesis and vascular abnormalization as well as metastasis | 29355844 |
| 2018-03-10 12:02:00 | We identified colorectal cancer as a novel Tie1-expressing tumor, with Tie1-positive cells hardly detectable in the normal intestine. Tie1 expression did not influence cancer cell proliferation in regular in vitro cultures, but significantly affected malignant growth of transplanted tumors in vivo. | 28464467 |
| Type | IDs |
|---|---|
| Synonymous | JTK14, TIE |
| Gene |
UniProtKB-ID:
TIE1_HUMAN,
B4DTW8_HUMAN
UniprotKB:
P35590,
B4DTW8
UniParc:
UPI00017A7F17,
UPI0000032E59,
UPI000067CA81,
UPI000067CA84
EMBL:
X60957,
AK300399,
BC038239,
EU826588,
AL139289,
EU826587,
AC093420
Ensembl:
ENSG00000066056
KO:
hsa:7075
|
| Nucleutide sequences |
EMBL-CDS:
ACF47624.1,
CAA43290.1,
ACF47623.1,
AAH38239.1,
BAG62130.1
Ensembl_TRS:
ENST00000538015,
ENST00000372476
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000440063,
ENSP00000361554
RefSeq:
XP_005271220.1,
XP_016857696.1,
XP_006710932.1,
NP_001240286.1,
NP_005415.1
|
| Others |
UniRef100:
UniRef100_P35590,
UniRef100_B4DTW8
UniRef90:
UniRef90_P35590
UniRef50:
UniRef50_P35590
UniGene:
Hs.78824
CCDS:
CCDS482.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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