| Type | Description |
|---|---|
| Definition | p21 (RAC1) activated kinase 4 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:15:00 | PAK4 suppresses motor neuron degeneration in hSOD1(G93A) -linked amyotrophic lateral sclerosis cell and rat models. | 33615605 |
| 2020-10-31 13:16:00 | Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletion. | 31594963 |
| 2019-12-14 11:29:00 | In mice, MMTV-PAK4 overexpression promotes spontaneous mammary cancer, while PAK4 gene depletion delays MMTV-PyMT driven tumors. | 31399573 |
| 2019-03-02 12:01:00 | Together, this suggests that PAK4 is dispensable for mouse pancreas development. | 28765528 |
| 2018-04-21 11:15:00 | PAK4 crystal structures can be classified into specific conformational groups, and that these groups are associated with previously unobserved hinging motions and an unusual conformation for the kinase hydrophobic core. Our findings therefore indicate that there may be a diversity of kinase hinging motions, and that these may indicate different mechanisms of regulation. | 28993291 |
| Type | IDs |
|---|---|
| Synonymous | 5730488L07Rik, AW555722, mKIAA1142 |
| Gene |
UniProtKB-ID:
PAK4_MOUSE
UniprotKB:
Q8BTW9
UniParc:
UPI00000EAAF4
EMBL:
AK129298,
AK017713,
AK088512,
BC048238,
AY217016
Ensembl:
ENSMUSG00000030602
KO:
mmu:70584
|
| Nucleutide sequences |
EMBL-CDS:
BAC98108.2,
AAH48238.1,
AAO61496.1,
BAB30889.1,
BAC40396.1
Ensembl_TRS:
ENSMUST00000108283,
ENSMUST00000032823
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000103918,
ENSMUSP00000032823
RefSeq:
NP_081746.1,
XP_017167786.1,
XP_017167785.1
|
| Others |
UniRef100:
UniRef100_Q8BTW9
UniRef90:
UniRef90_Q8BTW9
UniRef50:
UniRef50_Q8BTW9
UniGene:
Mm.21876
CCDS:
CCDS21049.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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