| Type | Description |
|---|---|
| Definition | unc-13 homolog D |
| Date | Results | Publications |
|---|---|---|
| 2020-10-31 13:14:00 | Defective Zn(2+) homeostasis in mouse and human platelets with alpha- and delta-storage pool diseases. | 31171812 |
| 2019-08-03 13:11:00 | we found that platelet-specific Munc13-4 KO mice had a reduction in airway hyper-responsiveness and eosinophilic inflammation. Taken together, our results indicate that Munc13-4-dependent platelet dense granule release plays essential roles in hemostasis, thrombosis and allergic inflammation. | 29674495 |
| 2019-07-06 10:32:00 | these results demonstrate that both C2 domains of Munc13-4 play critical roles in Ca(2+)-dependent exocytosis and cytotoxicity by regulating single-granule membrane fusion dynamics in immune cells | 29884704 |
| 2018-12-01 10:13:00 | In a model of systemic anaphylaxis, we found no difference between WT and Munc13-2 KO mice, but global and mast cells-specific Munc13-4 KO mice developed less hypothermia. We conclude that although Munc13-2 plays a minor role, Munc13-4 is essential for regulated exocytosis in mast cells | 29141910 |
| 2016-10-29 11:59:00 | Munc13-4 is a syntaxin 7 binding protein and an important regulator of late endosome maturation. | 26680738 |
| Type | IDs |
|---|---|
| Synonymous | 2610108D09Rik, Jinx, Munc13-4, mFLJ00067 |
| Gene |
UniProtKB-ID:
UN13D_MOUSE,
Q80UG7_MOUSE
UniprotKB:
B2RUP2,
Q80UG7
UniParc:
UPI000024E227,
UPI000000BA10,
UPI00004F8E21
EMBL:
AK220199,
EF127646,
BC141289,
BC046519,
AL607108,
EF127645
Ensembl:
ENSMUSG00000057948
KO:
mmu:70450
|
| Nucleutide sequences |
EMBL-CDS:
AAI41290.1,
ABO15439.1,
BAD90124.1,
ABO15440.1,
AAH46519.1
Ensembl_TRS:
ENSMUST00000174822,
ENSMUST00000106450,
ENSMUST00000075036,
ENSMUST00000106451
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000102058,
ENSMUSP00000102059,
ENSMUSP00000074549,
ENSMUSP00000134260
RefSeq:
XP_006534253.1,
NP_001009573.2,
XP_006534252.1,
XP_006534251.1,
XP_006534255.1
|
| Others |
UniRef100:
UniRef100_Q80UG7,
UniRef100_B2RUP2
UniRef90:
UniRef90_B2RUP2,
UniRef90_Q80UG7
UniRef50:
UniRef50_Q80UG7,
UniRef50_Q70J99
UniGene:
Mm.259460
CCDS:
CCDS25656.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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