| Type | Description |
|---|---|
| Definition | transferrin receptor 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-15 10:30:00 | Transferrin receptor 1 (TfR1) mediates cellular uptake of holo-Tf and H-ferritin; New World arenaviruses and Plasmodium vivax use TfR1 for entry into host cells. In hepatocytes, TfR2 forms a complex with HFE and serves as an iron sensor. In erythroblasts, TfR2 forms a complex with EPO receptor and regulates erythropoiesis. | 29969719 |
| 2019-12-21 10:41:00 | TfR2 -Y250X and TfR1-rs3817672 SNP showed clinical association with iron deficiency anemia | 31793267 |
| 2018-05-12 11:29:00 | In agreement with previous studies with truncated forms of these receptors, holo-Tf binds to the TfR1 homologue significantly stronger than to TfR2. | 29388418 |
| 2018-02-24 11:06:00 | Authors retrospectively investigated whether TFR2 isoforms and EPOR are differentially expressed in MDS patients and whether the expression is associated with patients' clinical outcomes. | 26914246 |
| 2018-01-13 10:05:00 | unreported iron metabolism-related genes in non-classic hereditary hemochromatosis patients that were predicted to be potentially pathogenic were three novel mutations in TFR2 [two missense (p.Leu750Pro and p.Ala777Val) and one intronic splicing mutation (c.967-1G>C)], one missense mutation in HFE (p.Tyr230Cys), and one mutation in the 5'-UTR of HAMP gene (c.-25G>A) | 27667161 |
| Type | IDs |
|---|---|
| Synonymous | HFE3, TFRC2 |
| Gene |
UniProtKB-ID:
TFR2_HUMAN
UniprotKB:
Q9UP52
UniParc:
UPI000002B535,
UPI0000136C99,
UPI000002B536
EMBL:
AF067864,
DQ496110,
AK022002,
AF053356,
BC142630,
AC099394,
AK000421
Ensembl:
ENSG00000106327
KO:
hsa:7036
|
| Nucleutide sequences |
EMBL-CDS:
ABF47099.1,
AAD45561.1,
AAC78796.1,
BAB13951.1,
AAI42631.1,
BAA91153.1
Ensembl_TRS:
ENST00000462107,
ENST00000223051
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000223051,
ENSP00000420525
RefSeq:
NP_001193784.1,
NP_003218.2
|
| Others |
UniRef100:
UniRef100_Q9UP52
UniRef90:
UniRef90_Q9UP52
UniRef50:
UniRef50_Q9UP52
UniGene:
Hs.544932
CCDS:
CCDS34707.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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