| Type | Description |
|---|---|
| Definition | ring finger protein 168 |
| Date | Results | Publications |
|---|---|---|
| 2020-09-19 12:26:00 | E3 ubiquitin ligase RNF168, in addition to its canonical role in inhibiting end resection, acts in a redundant manner with BRCA1 to load PALB2 onto damaged DNA. Loss of RNF168 negates the synthetic rescue of BRCA1 deficiency by 53BP1 deletion and it predisposes BRCA1 heterozygous mice to cancer. | 30704900 |
| 2019-04-13 10:47:00 | The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168 in embryonic fibroblasts. | 29403037 |
| 2018-09-15 10:52:00 | RNF168 interacts with TOP2alpha to mediate its polyubiquitylation and RNF168 deficiency confers resistance to ICRF-193, a TOP2 catalytic inhibitor, and cytotoxic anti-cancer drug etoposide in cultured mouse cells. | 27558965 |
| 2017-12-30 10:58:00 | The findings demonstrate that RNF168 couples PALB2-dependent homologous recombination to H2A ubiquitylation to promote DNA repair and preserve genome integrity. | 28240985 |
| 2013-11-02 10:17:00 | RNF168, in complex with RAD6A or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade. | 23525009 |
| Type | IDs |
|---|---|
| Synonymous | 3110001H15Rik |
| Gene |
UniProtKB-ID:
RN168_MOUSE,
E9PYW4_MOUSE
UniprotKB:
Q80XJ2,
E9PYW4
UniParc:
UPI00001EA6A5,
UPI000166C195
EMBL:
AC126265,
BC046815
Ensembl:
ENSMUSG00000014074
KO:
mmu:70238
|
| Nucleutide sequences |
EMBL-CDS:
AAH46815.1
Ensembl_TRS:
ENSMUST00000014218,
ENSMUST00000171474
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000014218,
ENSMUSP00000126484
RefSeq:
NP_081631.2
|
| Others |
UniRef100:
UniRef100_Q80XJ2
UniRef90:
UniRef90_Q80XJ2
UniRef50:
UniRef50_Q8IYW5
UniGene:
Mm.228263
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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