| Type | Description |
|---|---|
| Definition | WNK lysine deficient protein kinase 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-22 15:27:00 | WNK4 limits distal calcium losses following acute furosemide treatment. | 31496133 |
| 2020-08-01 11:17:00 | Results show that the serine/threonine-protein kinase WNK4 (WNK4)-serine/threonine-protein kinase 39 transport protein (NKCC1) cascade plays an important role in modulating macrophage activation to regulate lipopolysaccharides (LPS)-induced lung inflammation and lung injury. | 31786261 |
| 2020-05-09 10:34:00 | We postulate a model of distal convoluted tubule function in which NCC activity is modulated by plasma K(+) concentration via interactions within WNK bodies. | 31736353 |
| 2020-04-11 12:38:00 | single delivery of the vector pair into the mature cochlea of Otof (-/-) mutant mice reconstituted the otoferlin cDNA coding sequence through recombination of the 5' and 3' cDNAs, leading to the durable restoration of otoferlin expression in transduced cells and a reversal of the deafness phenotype, raising hopes for future gene therapy trials in DFNB9 patients | 30765526 |
| 2020-01-11 12:14:00 | This study demonstrates that CLDN7 plays an important role in salt balance in renal CD cells and modulating WNK4 and ENaC expression levels that are vital in controlling salt-sensitive hypertension. | 31382627 |
| Type | IDs |
|---|---|
| Synonymous | 2010002J11Rik, Pha2b, Prkwnk4 |
| Gene |
UniProtKB-ID:
WNK4_MOUSE
UniprotKB:
Q80UE6
UniParc:
UPI000000603C
EMBL:
AL590969,
BC096453,
AY184228,
BC043677,
AY187027,
BC026591,
BC026679
Ensembl:
ENSMUSG00000035112
KO:
mmu:69847
|
| Nucleutide sequences |
EMBL-CDS:
AAO21955.1,
AAH26679.1,
AAH43677.1,
AAH96453.1,
AAH26591.1,
AAO25619.1
Ensembl_TRS:
ENSMUST00000103108
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000099397
RefSeq:
XP_006534202.1,
NP_783569.1,
XP_017170233.1,
XP_036012863.1,
XP_006534199.1,
XP_006534204.1,
XP_006534201.1,
XP_006534200.1
|
| Others |
UniRef100:
UniRef100_Q80UE6
UniRef90:
UniRef90_Q80UE6
UniRef50:
UniRef50_Q96J92
UniGene:
Mm.23656
CCDS:
CCDS25459.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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