| Type | Description |
|---|---|
| Definition | F-box protein 7 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 11:11:00 | Loss of Fbxo7 in myelinating glia led to axonal degeneration in the CNS and peripheral neuropathy. | 31085610 |
| 2020-04-18 10:58:00 | The neuroprotective role of FBXO7 involves its suppression of the RPL23-MDM2-p53 axis that promotes cell death in dopaminergic midbrain neurons. | 31144295 |
| 2019-11-30 12:08:00 | Fbxo7 hypomorphs were produced at a normal Mendelian ratio with a normal lifespan and no evidence of neurological symptoms. These data suggest that erythrocyte survival, T cell development and spermatogenesis are particularly sensitive to Fbxo7 gene dosage. | 30840666 |
| 2017-08-19 10:18:00 | Fbxo7-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 levels. These studies reveal differential cell cycle regulation by Fbxo7 at different stages in T-cell development. | 27915416 |
| 2017-07-01 13:01:00 | Taken together, this study establishes a vital role for FBXO7 in neurons, which is required for proper motor control and accentuates the importance of FBXO7 in proteasome function. | 27497298 |
| Type | IDs |
|---|---|
| Synonymous | 2410015K21Rik, A230052G17Rik, AI117679, AW260462, C85118 |
| Gene |
UniProtKB-ID:
FBX7_MOUSE,
Q3UGI9_MOUSE,
Q3UD93_MOUSE
UniprotKB:
Q3U7U3,
Q3UGI9,
Q3UD93
UniParc:
UPI00005AC70E,
UPI00005AC98C,
UPI000019283E
EMBL:
AK147797,
AK147907,
AK150626,
AK151025,
AK150190,
CH466539,
AC122919,
BC032153,
AK152513
Ensembl:
ENSMUSG00000001786
KO:
mmu:69754
|
| Nucleutide sequences |
EMBL-CDS:
EDL21433.1,
BAE30043.1,
BAE31276.1,
BAE29716.1,
BAE28145.1,
AAH32153.1,
BAE28219.1,
BAE29368.1
Ensembl_TRS:
ENSMUST00000130320,
ENSMUST00000117597,
ENSMUST00000120344
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000120840,
ENSMUSP00000113263,
ENSMUSP00000113222
RefSeq:
XP_011241858.1,
NP_001297674.1,
XP_017169566.1,
NP_001334080.1,
NP_694875.2
|
| Others |
UniRef100:
UniRef100_Q3U7U3,
UniRef100_Q3UD93
UniRef90:
UniRef90_Q3U7U3
UniRef50:
UniRef50_Q9Y3I1-2
UniGene:
Mm.44236
CCDS:
CCDS24095.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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