| Type | Description |
|---|---|
| Definition | ribonuclease H2, large subunit |
| Date | Results | Publications |
|---|---|---|
| 2019-12-14 11:05:00 | An RNase H2 mutant lacking ribonucleotide excision repair activity but supporting R-loop removal revealed that ribonucleotides in DNA initiate p53-dependent DNA damage response and early embryonic arrest in mouse. | 30380406 |
| 2016-07-30 10:35:00 | the G37S mutation of RNaseH2 led to increased expression of interferon-stimulated genes dependent on the cGAS-STING signaling pathway. | 26880576 |
| 2014-06-07 12:53:00 | Recent evidence gathered from ribonuclease H2 knock-out mice provides insight into the molecular mechanisms underlying Aicardi-Goutieres syndrome development and a potential role of DNA damage as a trigger of autoimmunity is discussed. [review] | 23744109 |
| 2011-07-16 11:30:00 | analysis of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome | 21454563 |
| 2010-04-12 12:17:00 | Data show that the interwoven architecture of RNase H2B and RNase H2C that interface with RNase H2A in a complex ideally suited for nucleic acid binding and hydrolysis coupled to protein-protein interaction motifs. | 19923215 |
| Type | IDs |
|---|---|
| Synonymous | 2400006P09Rik, RNASEHI, RNHIA, RNHL |
| Gene |
UniProtKB-ID:
RNH2A_MOUSE
UniprotKB:
Q9CWY8
UniParc:
UPI0000023853
EMBL:
AK010292,
AK146518,
BC038158
Ensembl:
ENSMUSG00000052926
KO:
mmu:69724
|
| Nucleutide sequences |
EMBL-CDS:
BAE27230.1,
AAH38158.1,
BAB26828.1
Ensembl_TRS:
ENSMUST00000147812,
ENSMUST00000109738,
ENSMUST00000109736
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000105358,
ENSMUSP00000105360,
ENSMUSP00000120374
RefSeq:
NP_001351299.1,
XP_011246799.1,
NP_081463.1
|
| Others |
UniRef100:
UniRef100_Q9CWY8
UniRef90:
UniRef90_Q9CWY8
UniRef50:
UniRef50_O75792
UniGene:
Mm.182470
CCDS:
CCDS22486.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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