| Type | Description |
|---|---|
| Definition | Rho guanine nucleotide exchange factor (GEF) 12 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-01 11:07:00 | Here, the authors show that small arteries from mice with smooth muscle-specific loss of G12/G13 or the Rho guanine nucleotide exchange factor ARHGEF12 have lost myogenic vasoconstriction. | 31549965 |
| 2019-03-23 11:04:00 | mechanical activation of RhoA in mesenchymal progenitors is dependent on LARG, while ARHGAP18 limits RhoA delineated cytoskeletal structure in static cultures | 29208526 |
| 2018-02-03 10:03:00 | We studied the function of LARG in murine and human megakaryocytes and platelets with Larg knockout (KO), shRNA-mediated knockdown and small molecule-mediated inhibition. We found that LARG is important for human, but not murine, megakaryocyte maturation. | 27345948 |
| 2017-12-30 12:24:00 | Data found an inverse relationship between the expression of miR-660 and ARHGEF12 in both gain- and loss-of-function studies: overexpression of miR-660 declined the mRNA and protein expressions of ARHGEF12 in C2C12 cells differentiation; however, knockdown of miR-660 had completely opposite results. | 28106300 |
| 2017-10-14 12:49:00 | This study demonstrated an almost 100-fold higher agonist sensitivity of the Galpha13 LARG interaction compared to the Galpha13 activation in the absence of LARG. | 28465324 |
| Type | IDs |
|---|---|
| Synonymous | 2310014B11Rik, AU019857, Larg, mKIAA0382 |
| Gene |
UniProtKB-ID:
F8VQN6_MOUSE
UniprotKB:
F8VQN6
UniParc:
UPI0001335890
EMBL:
AC160123,
AC110169
Ensembl:
ENSMUSG00000059495
|
| Nucleutide sequences |
Ensembl_TRS:
ENSMUST00000165665
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000126598
RefSeq:
XP_011240899.1,
NP_001346161.1,
XP_036011146.1,
XP_011240900.1,
XP_017169054.1,
XP_030100432.1,
NP_081420.2,
XP_030100433.1,
XP_017169055.1,
XP_036011147.1,
XP_017169056.1,
XP_030100431.1
|
| Others |
UniRef100:
UniRef100_F8VQN6
UniRef90:
UniRef90_F8VQN6
UniRef50:
UniRef50_Q9NZN5
UniGene:
Mm.275266
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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