| Type | Description |
|---|---|
| Definition | AFG3-like AAA ATPase 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-06 13:57:00 | Our data identify the earliest events in SCA28 pathogenesis and open new perspectives for therapy. By identifying similar mitochondrial phenotypes between SCA28 cells and AFG3L2(+/-) cells, our results support haploinsufficiency as the mechanism for the studied pathogenic variants. | 30910913 |
| 2020-04-25 12:08:00 | Upregulation of Peroxiredoxin 3 Protects Afg3l2-KO Cortical Neurons In Vitro from A Paradigm for Neuronal Cell Survival under Neurodegenerative Conditions. | 31781336 |
| 2020-02-15 10:05:00 | Astrocyte-specific deletion of Afg3l2 in the mouse leads to late-onset motor impairment and to degeneration of BG, which display aberrant morphology, altered expression of the glutamate transporter EAAT2, and a reactive inflammatory signature. The neurological and glial phenotypes are drastically exacerbated when astrocytes lack both Afg31l and Afg3l2, and therefore, are totally depleted of the m-AAA protease. | 30989755 |
| 2017-05-13 18:43:00 | total ablation of the m-AAA protease, by deleting both Afg3l2 and its paralogue Afg3l1, triggers progressive motor dysfunction and demyelination, owing to rapid oligodendrocyte cell death | 27911893 |
| 2016-02-20 11:55:00 | AFG3L2 is critical to the surveillance mechanism that acts as a sensor to couple the synthesis of mitochondrial proteins with organelle fitness, thus ensuring coordinated assembly of the oxidative phosphorylation complexes from two sets of ribosomes. | 26504172 |
| Type | IDs |
|---|---|
| Synonymous | 2310036I02Rik, AW260507, Emv66, par |
| Gene |
UniProtKB-ID:
AFG32_MOUSE
UniprotKB:
Q8JZQ2
UniParc:
UPI000002966E
EMBL:
BC036999,
BC043056
Ensembl:
ENSMUSG00000024527
KO:
mmu:69597
|
| Nucleutide sequences |
EMBL-CDS:
AAH36999.1,
AAH43056.1
Ensembl_TRS:
ENSMUST00000025408
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000025408
RefSeq:
NP_081406.1,
XP_036017166.1,
XP_011245300.1,
XP_036017167.1
|
| Others |
UniRef100:
UniRef100_Q8JZQ2
UniRef90:
UniRef90_Q8JZQ2
UniRef50:
UniRef50_Q9Y4W6
UniGene:
Mm.426052
CCDS:
CCDS37847.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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