| Type | Description |
|---|---|
| Definition | Bruton tyrosine kinase |
| Date | Results | Publications |
|---|---|---|
| 2021-03-06 13:33:00 | BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID-19 therapy. | 32640487 |
| 2021-02-13 13:29:00 | Novel BCL2 mutations in venetoclax-resistant, ibrutinib-resistant CLL patients with BTK/PLCG2 mutations. | 32232486 |
| 2021-02-13 13:24:00 | Bruton's tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis. | 32484802 |
| 2021-01-02 12:48:00 | Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1beta-mediated colitis. | 31895698 |
| 2020-12-26 13:13:00 | Noncatalytic Bruton's tyrosine kinase activates PLCgamma2 variants mediating ibrutinib resistance in human chronic lymphocytic leukemia cells. | 32184360 |
| Type | IDs |
|---|---|
| Synonymous | AGMX1, AT, ATK, BPK, IGHD3, IMD1, PSCTK1, XLA |
| Gene |
UniProtKB-ID:
BTK_HUMAN,
Q5JY90_HUMAN
UniprotKB:
Q06187,
Q5JY90
UniParc:
UPI000013C51A,
UPI000021216F,
UPI0000126B16
EMBL:
U10084,
U13417,
U13431,
U13413,
BC109079,
U13415,
U10087,
U13414,
U13433,
L31563,
L31557,
U13432,
L31561,
AK314382,
U78027,
L31572,
U13429,
U10086,
L31565,
U13428,
CH471115,
L31567,
U13425,
L31568,
U13423,
U13424,
L31564,
X58957,
L31566,
L31569,
U13412,
L31559,
U13427,
AK057105,
U10085,
L31570,
AL035422,
U13416,
U13422,
U13430,
U13410,
L31571,
L31558,
BC109080
Ensembl:
ENSG00000010671
KO:
hsa:695
|
| Nucleutide sequences |
EMBL-CDS:
BAG37008.1,
AAC51347.1,
AAA61479.1,
AAB60639.1,
AAI09081.1,
AAB64205.1,
AAI09080.1,
CAA41728.1,
BAG51864.1,
EAX02857.1
Gene_ORFName:
hCG_20400
Ensembl_TRS:
ENST00000308731,
ENST00000621635,
ENST00000372880
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000308176,
ENSP00000483570,
ENSP00000361971
RefSeq:
NP_001274274.1,
NP_001274273.1,
NP_000052.1
|
| Others |
UniRef100:
UniRef100_Q5JY90,
UniRef100_Q06187
UniRef90:
UniRef90_Q5JY90,
UniRef90_Q06187
UniRef50:
UniRef50_Q06187,
UniRef50_Q5JY90
UniGene:
Hs.159494
CCDS:
CCDS14482.1,
CCDS76003.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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