| Type | Description |
|---|---|
| Definition | ubiquitin protein ligase E3 component n-recognin 4 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:35:00 | Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging. | 33658508 |
| 2020-08-22 15:31:00 | A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy in Drosophila and Mice. | 31365869 |
| 2019-02-09 11:59:00 | UBR4-deficient mouse embryos suffer from multiple abnormalities in neurogenesis and other developmental processes. Histological and cytological examinations suggest that the cells in mutant embryos fail to maintain their morphology and adhesion, leading to failure to communicate with each other and advance into more differentiated stages. | 30157281 |
| 2017-01-28 10:22:00 | Ubiquitin ligase Ubr4 is a key component of the podocin interactome purified from cultured podocytes and native glomeruli. Ubiquitylomic analysis of mouse glomeruli revealed that podocin is ubiquitylated at two lysine residues. Ubiquitylation of one podocin site, K301, do not only target podocin for proteasomal degradation, but may also affect stability and disassembly of the multimeric complex. | 26792178 |
| 2015-04-25 11:51:00 | This study is the first to identify a novel E3 ubiquitin ligase component, UBR4, in the murine SCN and to implicate the N-end rule degradation pathway as a potential player in regulating core clock mechanisms and photic entrainment. | 25084275 |
| Type | IDs |
|---|---|
| Synonymous | 1810009A16Rik, A930005E13Rik, D930005K06Rik, Gm1032, Gm1666, N28143, RBAF600, Zubr1, mKIAA0462, p600 |
| Gene |
UniProtKB-ID:
UBR4_MOUSE
UniprotKB:
A2AN08
UniParc:
UPI000059E299,
UPI00001F189F,
UPI000150AF3C,
UPI000150AF37,
UPI000150AF38
EMBL:
AK083644,
AK082231,
AK044277,
BC057625,
BC059890,
BC094329,
BC051096,
AL807833,
AB093242,
BC040468,
AK086097,
AK080556
Ensembl:
ENSMUSG00000066036
KO:
mmu:69116
|
| Nucleutide sequences |
EMBL-CDS:
BAC37944.1,
AAH51096.1,
BAC38980.2,
AAH40468.1,
BAC31850.1,
BAC38442.2,
AAH57625.1,
AAH59890.1,
AAH94329.1,
BAC41426.2,
BAC39609.1
Ensembl_TRS:
ENSMUST00000165860,
ENSMUST00000097822
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000125800,
ENSMUSP00000095433
RefSeq:
NP_001153791.1
|
| Others |
UniRef100:
UniRef100_A2AN08
UniRef90:
UniRef90_Q5T4S7
UniRef50:
UniRef50_Q5T4S7
UniGene:
Mm.271956
CCDS:
CCDS51340.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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