| Type | Description |
|---|---|
| Definition | proline-rich transmembrane protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 11:41:00 | Constitutive Inactivation of the PRRT2 Gene Alters Short-Term Synaptic Plasticity and Promotes Network Hyperexcitability in Hippocampal Neurons. | 29912316 |
| 2020-01-04 12:03:00 | Prrt2 deletion causes spontaneous paroxysmal episodes with seizure, movement disorders and spatial learning deficits. | 30884140 |
| 2019-09-14 10:48:00 | these findings identify PRRT2 as a novel regulator of the SNARE complex and provide a circuit mechanism underlying the PRRT2-related behaviors. | 29056747 |
| 2018-02-24 11:31:00 | Study describes the phenotype of KO mice for PRRT2 and shows that its loss-of-function recapitulates the human phenotype in terms of episodic disturbances in motor coordination and paroxysmal dyskinesias, suggesting that PRRT2 plays a critical role in the development of cortical connectivity and functional stability of neuronal networks. | 28007585 |
| 2018-01-27 10:35:00 | PRRT2 mutations have roles in neuronal dysfunction and neurodevelopmental defects | 27172900 |
| Type | IDs |
|---|---|
| Synonymous | 1500031I19Rik, AI195361, DSPB3 |
| Gene |
UniProtKB-ID:
PRRT2_MOUSE
UniprotKB:
E9PUL5
UniParc:
UPI0000218672
EMBL:
AC122863
Ensembl:
ENSMUSG00000045114
KO:
mmu:69017
|
| Nucleutide sequences |
Ensembl_TRS:
ENSMUST00000159916
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000124520
RefSeq:
NP_001096033.1,
XP_036009308.1,
XP_036009307.1,
XP_036009306.1
|
| Others |
UniRef100:
UniRef100_E9PUL5
UniRef90:
UniRef90_E9PUL5
UniRef50:
UniRef50_Q7Z6L0-3
UniGene:
Mm.392047
CCDS:
CCDS52405.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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