| Type | Description |
|---|---|
| Definition | ryanodine receptor 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 11:52:00 | results provide preclinical experimental evidence that the cardiac expression of RyR2 nanobodies with AAV9 vectors is a promising therapeutic strategy for heart failure | 30885011 |
| 2019-10-05 12:14:00 | The present novel results emphasize the key role of redox-sensitive Ca(2+) release mediated by RyR2 channels for hippocampal structural plasticity and spatial memory. | 29357673 |
| 2018-12-01 11:25:00 | Study shows that contextual fear memory formation and destabilization induce hippocampal ryanodine receptor (RyR2) calcium channel upregulation. The study proposes that both fear consolidation and extinction memories induce RyR2 protein upregulation in order to generate the intracellular Ca(2+) signals required for these distinct memory processes. | 30123252 |
| 2017-12-23 12:29:00 | RyR-2 regulated TGFbeta1 expression in mechanically stretched cardiomyocytes, and TGFbeta1 promoted collagen formation of cardiac fibroblasts by a paracrine mechanism. | 29162778 |
| 2017-08-26 11:06:00 | Data, including data from studies in vesicles of knockout mice, suggest pathophysiological levels of Zn2+ (>2nM) cause dysregulation of RyR2 opening; in sarcoplasmic reticulum, RyR2 are not the only Ca2+-channels regulated by Zn2+; in cardiomyocytes exposed to ischemic/hypoxic conditions, intracellular Zn2+ levels are elevated, coinciding with increased MG23 expression. (RyR2 = ryanodine receptor 2; MG23 = mitsugumin 23) | 28630041 |
| Type | IDs |
|---|---|
| Synonymous | RYR-2, RyR |
| Gene |
UniProtKB-ID:
RYR2_RAT
UniprotKB:
B0LPN4
UniParc:
UPI00024B9D2B,
UPI00024B9D2A
EMBL:
EU346200,
AB204523
KO:
rno:689560
|
| Nucleutide sequences |
EMBL-CDS:
ABY79796.1,
BAJ10276.1
|
| Protein sequencees |
RefSeq:
NP_114467.1,
NP_001177972.2
|
| Others |
UniRef100:
UniRef100_B0LPN4
UniRef90:
UniRef90_B0LPN4
UniRef50:
UniRef50_B0LPN4
UniGene:
Rn.20442
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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