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6895 TARBP2

6895

TARBP2

TARBP2 subunit of RISC loading complex

protein-coding

Homo sapiens

基因描述

Type Description
Definition TARBP2 subunit of RISC loading complex

研究结论

Date Results Publications
2021-03-20 13:35:00 TARBP2 promotes tumor angiogenesis and metastasis by destabilizing antiangiogenic factor mRNAs. 33484209
2021-02-27 13:49:00 Hypoxia-induced let-7f-5p/TARBP2 feedback loop regulates osteosarcoma cell proliferation and invasion by inhibiting the Wnt signaling pathway. 32305960
2020-03-21 10:35:00 Our findings may shed light on the mechanism of apoptosis, induced by the TRBP-bound miRNAs through the interaction of TRBP with LGP2, as an antiviral defense system in mammalian cells. 31799626
2020-02-01 11:31:00 TARBP2 affects tumor growth in the lung and that this is dependent on TARBP2-mediated destabilization of ABCA3 and FOXN3. Finally, we establish ZNF143 as an upstream regulator of TARBP2 expression. 31300274
2019-12-07 10:11:00 The TARBP2 protein was destabilized through autophagic-lysosomal proteolysis, thereby stabilizing the expression of the cancer stem cell marker protein Nanog, which facilitates sorafenib resistance in Hepatocellular carcinoma cells. 30657254

名称对应

Type IDs
Synonymous LOQS, TRBP, TRBP1, TRBP2
Gene
UniProtKB-ID: TRBP2_HUMAN, A0A024RB49_HUMAN
UniprotKB: Q15633, A0A024RB49
UniParc: UPI0000161197, UPI00001FC3AD, UPI0000071D96
EMBL: M60801, U08998, BT007140, AF281068, BC005860, CH471054
Ensembl: ENSG00000139546
KO: hsa:6895
Nucleutide sequences
EMBL-CDS: EAW96720.1, AAP35804.1, AAB50581.2, AAL55731.1, AAL55730.1, AAH05860.1, AAA36765.1, EAW96719.1, EAW96718.1
Gene_ORFName: hCG_23345
Ensembl_TRS: ENST00000456234, ENST00000394357, ENST00000266987
Protein sequencees
Ensembl_PRO: ENSP00000416077, ENSP00000266987, ENSP00000377885
RefSeq: XP_005269179.1, XP_005269171.1, XP_016875399.1, XP_005269177.1, XP_005269172.1, XP_016875400.1, NP_599151.2, XP_011537014.1, XP_006719644.1, NP_004169.3, XP_005269174.1, NP_599150.1
Others
UniRef100: UniRef100_A0A024RB49, UniRef100_Q15633
UniRef90: UniRef90_Q15633
UniRef50: UniRef50_Q15633
UniGene: Hs.326
CCDS: CCDS8861.1, CCDS41791.1

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