| Type | Description |
|---|---|
| Definition | charged multivesicular body protein 2B |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:26:00 | Longitudinal transcriptomic analysis of altered pathways in a CHMP2B(intron5)-based model of ALS-FTD. | 31837425 |
| 2020-05-30 12:57:00 | Results suggest dysregulation of CHMP2B together with tau-pathology and possibly a disturbance of the regulation of vesicular compartments. The absence of combined Abeta- and tau-associated pathology in the transgenic mice may account for the difference in CHMP2B-immunoreactivity between the transgenic mice and human hippocampus. | 30414727 |
| 2019-07-20 12:52:00 | Data show that the frontotemporal dementia (FTD)-causing C-terminal truncation of CHMP2B results in dendritic endolysosomal trafficking defects. Strikingly, we found that this trafficking defect could be rescued by the knockdown of the FTD risk factor Tmem106b. | 30496365 |
| 2019-02-09 12:55:00 | The pro-apoptotic JNK scaffold protein POSH mediates CHMP2BIntron5-associated toxicity in animal models of frontotemporal dementia. | 29432529 |
| 2017-11-18 12:17:00 | The presence of early microglial changes in our CHMP2B mutant mice indicates neuroinflammation may be a contributing factor to the neurodegeneration observed in FTD. | 28093491 |
| Type | IDs |
|---|---|
| Synonymous | 1190006E07Rik |
| Gene |
UniProtKB-ID:
CHM2B_MOUSE
UniprotKB:
Q8BJF9
UniParc:
UPI00000EB6DC
EMBL:
BC042626,
AK084111,
AK004506,
BC055809
Ensembl:
ENSMUSG00000004843
KO:
mmu:68942
|
| Nucleutide sequences |
EMBL-CDS:
BAC39118.1,
AAH42626.1,
BAB23339.1,
AAH55809.1
Ensembl_TRS:
ENSMUST00000004965
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000004965
RefSeq:
XP_036015999.1,
NP_081155.1
|
| Others |
UniRef100:
UniRef100_Q8BJF9
UniRef90:
UniRef90_Q8BJF9
UniRef50:
UniRef50_Q8BJF9
UniGene:
Mm.432944
CCDS:
CCDS28269.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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