| Type | Description |
|---|---|
| Definition | betacellulin |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:52:00 | Betacellulin enhances ovarian cancer cell migration by up-regulating Connexin43 via MEK-ERK signaling. | 31654720 |
| 2019-05-04 11:34:00 | Despite both ligands binding to the EGFR, BTC biases the EGFR to dimerize with ErbB3 to regulate the biologic response. | 30249613 |
| 2018-01-13 12:53:00 | Our results suggest that betacellulin induces ovarian cancer migration and Slug-dependent E-cadherin down-regulation | 27129169 |
| 2014-09-06 10:52:00 | CXCL8 production from lung cancer cells could be initiated by an autocrine mechanism or external sources of BTC. | 24629040 |
| 2014-04-19 11:52:00 | Data suggest that BTC (betacellulin), AREG (amphiregulin), and EREG (epiregulin) induced prostaglandin E2 production by induction of COX-2 (prostaglandin-endoperoxide synthase 2) through MAP kinase signaling in granulosa cells. | 24092824 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
BTC_HUMAN,
A0A0S2Z437_HUMAN,
A0A0S2Z3I5_HUMAN
UniprotKB:
P35070,
A0A0S2Z437,
A0A0S2Z3I5
UniParc:
UPI000020AFFD,
UPI0000126B08
EMBL:
KU177947,
BC011618,
S55606,
CH471057,
KU177946
Ensembl:
ENSG00000174808
KO:
hsa:685
|
| Nucleutide sequences |
EMBL-CDS:
AAB25452.1,
AAH11618.1,
EAX05712.1,
ALQ33404.1,
ALQ33405.1
Gene_ORFName:
hCG_24384
Ensembl_TRS:
ENST00000395743
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000379092
RefSeq:
NP_001303892.1,
XP_011530513.1,
NP_001720.1,
XP_016864057.1
|
| Others |
UniRef100:
UniRef100_P35070,
UniRef100_A0A0S2Z3I5
UniRef90:
UniRef90_P35070,
UniRef90_A0A2K6LUA3
UniRef50:
UniRef50_A0A6G1BDD5,
UniRef50_P35070
UniGene:
Hs.710156
CCDS:
CCDS3566.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32296183 |
A reference map of the human binary protein interactome. Nature Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G Coté , Meaghan Daley , Steven Deimling , Alice Desbuleux , Amélie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , István A Kovács , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat TaÅan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood |
2020-04-01 | - |
| 31654720 |
Cell Signal Jianfang Zhao , Christian Klausen , Yuyin Yi , Jung-Chien Cheng , Hsun-Ming Chang , Peter C K Leung |
2020-01-01 | - |
| 30249613 |
Betacellulin (BTC) Biases the EGFR To Dimerize with ErbB3. Mol. Pharmacol. Jamie S Rush , Joanne L Peterson , Brian P Ceresa |
2018-12-01 | - |
| 29997244 |
Mol. Syst. Biol. Philipp Trepte , Sabrina Kruse , Simona Kostova , Sheila Hoffmann , Alexander Buntru , Anne Tempelmeier , Christopher Secker , Lisa Diez , Aline Schulz , Konrad Klockmeier , Martina Zenkner , Sabrina Golusik , Kirstin Rau , Sigrid Schnoegl , Craig C Garner , Erich E Wanker |
2018-07-11 | - |
| 27129169 |
Oncotarget Jianfang Zhao , Christian Klausen , Xin Qiu , Jung-Chien Cheng , Hsun-Ming Chang , Peter C K Leung |
2016-05-17 | - |
| 26871637 |
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell Xinping Yang , Jasmin Coulombe-Huntington , Shuli Kang , Gloria M Sheynkman , Tong Hao , Aaron Richardson , Song Sun , Fan Yang , Yun A Shen , Ryan R Murray , Kerstin Spirohn , Bridget E Begg , Miquel Duran-Frigola , Andrew MacWilliams , Samuel J Pevzner , Quan Zhong , Shelly A Trigg , Stanley Tam , Lila Ghamsari , Nidhi Sahni , Song Yi , Maria D Rodriguez , Dawit Balcha , Guihong Tan , Michael Costanzo , Brenda Andrews , Charles Boone , Xianghong J Zhou , Kourosh Salehi-Ashtiani , Benoit Charloteaux , Alyce A Chen , Michael A Calderwood , Patrick Aloy , Frederick P Roth , David E Hill , Lilia M Iakoucheva , Yu Xia , Marc Vidal |
2016-02-11 |
USH1C,
PQBP1,
OPTN,
RBM5,
CDK5,
CDK7,
RABEPK,
SRRM1,
NOD1,
CD2BP2,
RBM14,
HAX1,
SLC30A9,
STK25,
SEMA4F,
SLC19A2,
CETP,
SRSF10,
SEPT9,
ALDH1L1,
RCC1,
LDB3,
AKAP10,
SEC63,
PHF21B,
HELQ,
CKB,
ERCC8,
CLCN2,
ZFYVE27,
CLPTM1,
TTC8,
C15orf40,
COL1A2,
BBS5,
ACMSD,
DNAJC19,
CPA2,
C7orf34,
CRH,
CRK,
RDH12,
MIPOL1,
ZNF688,
SLC25A10,
NKX2-5,
CTNS,
CTSD,
UPP2,
CYBB,
CYP11A1,
TSTD2,
DAO,
REM2,
DYX1C1,
DCN,
DDC,
GLIS3,
DGUOK,
DHCR7,
DMD,
E2F6,
TYMP,
EGR2,
FLCN,
EPHX1,
EYA4,
ETFA,
ETV6,
FANCC,
FANCG,
EFEMP1,
MICU2,
ZUFSP,
FCGR3A,
ABCB7,
FGA,
FGFR1,
FH,
DOLK,
KIAA0907,
ARHGEF15,
SETX,
ARHGAP26,
SPG20,
FMO3,
ETHE1,
SLC39A14,
CDK20,
SMUG1,
FXN,
FTSJ1,
MCM9,
GABRA2,
GAD1,
SUMF2,
GALT,
UNC50,
FBXO8
|
| 25910212 |
Widespread macromolecular interaction perturbations in human genetic disorders. Cell Nidhi Sahni , Song Yi , Mikko Taipale , Juan I Fuxman Bass , Jasmin Coulombe-Huntington , Fan Yang , Jian Peng , Jochen Weile , Georgios I Karras , Yang Wang , István A Kovács , Atanas Kamburov , Irina Krykbaeva , Mandy H Lam , George Tucker , Vikram Khurana , Amitabh Sharma , Yang-Yu Liu , Nozomu Yachie , Quan Zhong , Yun Shen , Alexandre Palagi , Adriana San-Miguel , Changyu Fan , Dawit Balcha , Amelie Dricot , Daniel M Jordan , Jennifer M Walsh , Akash A Shah , Xinping Yang , Ani K Stoyanova , Alex Leighton , Michael A Calderwood , Yves Jacob , Michael E Cusick , Kourosh Salehi-Ashtiani , Luke J Whitesell , Shamil Sunyaev , Bonnie Berger , Albert-László Barabási , Benoit Charloteaux , David E Hill , Tong Hao , Frederick P Roth , Yu Xia , Albertha J M Walhout , Susan Lindquist , Marc Vidal |
2015-04-23 | - |
| 25241761 |
J. Proteome Res. Tzu-Chi Chen , Kuan-Ting Lin , Chun-Houh Chen , Sheng-An Lee , Pei-Ying Lee , Yu-Wen Liu , Yu-Lun Kuo , Feng-Sheng Wang , Jin-Mei Lai , Chi-Ying F Huang |
2014-12-05 |
AKT3,
OCLN,
CDK2,
CDK4,
CDK6,
CDKN1A,
CDKN1B,
LOC400927-CSNK1E,
CDKN2B,
TAB1,
CREB3,
GNB5,
ADCY2,
RALBP1,
CHUK,
RASGRP4,
CLTC,
COL4A6,
ACVR1C,
CREB1,
ATF2,
CREBBP,
CRK,
CRKL,
MAPK14,
CSF1R,
CSF2RA,
CSNK1D,
CSNK1E,
CSNK2A1,
CREB3L4,
CTLA4,
CTNNA1,
CTNNB1,
CD55,
DGKA,
DAPK1,
DAXX,
GADD45A,
DFFA,
DLG1,
DOCK2,
DUSP1,
DUSP4,
DUSP9,
DVL1,
E2F1,
E2F2,
E2F3,
EGF,
EGFR,
EIF4EBP1,
ELK1,
CTTN,
EPAS1,
ERBB2,
ERBB3,
AKT1,
ERN1,
ETS1,
F2,
F2R,
F3,
F7,
F8,
F12,
PTK2B,
FCGR1A,
FCGR3A,
FGA,
FGF1,
FGF5,
A2M,
FGF8,
FGF10,
FGFR1,
FGFR2,
FGFR4,
FGG,
DKK1,
DAAM1,
FOXO1,
FOXO3,
TAB2,
FLNA,
FLT1,
FLT3LG,
FBXW11,
FN1,
FOS,
PIK3R5,
BACE1,
MTOR,
RICTOR,
FYN,
GAB1,
APPL1,
GHR,
CACYBP
|
| 25416956 |
A proteome-scale map of the human interactome network. Cell Thomas Rolland , Murat TaÅan , Benoit Charloteaux , Samuel J Pevzner , Quan Zhong , Nidhi Sahni , Song Yi , Irma Lemmens , Celia Fontanillo , Roberto Mosca , Atanas Kamburov , Susan D Ghiassian , Xinping Yang , Lila Ghamsari , Dawit Balcha , Bridget E Begg , Pascal Braun , Marc Brehme , Martin P Broly , Anne-Ruxandra Carvunis , Dan Convery-Zupan , Roser Corominas , Jasmin Coulombe-Huntington , Elizabeth Dann , Matija Dreze , Amélie Dricot , Changyu Fan , Eric Franzosa , Fana Gebreab , Bryan J Gutierrez , Madeleine F Hardy , Mike Jin , Shuli Kang , Ruth Kiros , Guan Ning Lin , Katja Luck , Andrew MacWilliams , Jörg Menche , Ryan R Murray , Alexandre Palagi , Matthew M Poulin , Xavier Rambout , John Rasla , Patrick Reichert , Viviana Romero , Elien Ruyssinck , Julie M Sahalie , Annemarie Scholz , Akash A Shah , Amitabh Sharma , Yun Shen , Kerstin Spirohn , Stanley Tam , Alexander O Tejeda , Shelly A Trigg , Jean-Claude Twizere , Kerwin Vega , Jennifer Walsh , Michael E Cusick , Yu Xia , Albert-László Barabási , Lilia M Iakoucheva , Patrick Aloy , Javier De Las Rivas , Jan Tavernier , Michael A Calderwood , David E Hill , Tong Hao , Frederick P Roth , Marc Vidal |
2014-11-20 | - |
| 24440602 |
The ABC of BTC: structural properties and biological roles of betacellulin. Semin. Cell Dev. Biol. Maik Dahlhoff , Eckhard Wolf , Marlon R Schneider |
2014-04-01 |
BTC
|
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|---|---|---|
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