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684527 Crtc1

684527

Crtc1

CREB regulated transcription coactivator 1

protein-coding

Rattus norvegicus

基因描述

Type Description
Definition CREB regulated transcription coactivator 1

研究结论

Date Results Publications
2019-12-07 10:24:00 a specific deletion of mTOR in Sertoli cells was found to cause an upregulation of p-rpS6-S240/S244 (i.e., an activation of rpS6), but not total rpS6, and was associated with blood-testis barrier disruption, epithelial damage, loss of cell polarity, and infertility. 31157869
2018-07-21 10:05:00 The PI3K/AKT pathway in the nucleus accumbens (NAc) of rodents plays a role in the molecular and behavioral adaptations that are induced by alcohol, and that in turn drives alcohol-drinking behaviors. 27766766
2018-03-10 10:30:00 blockade of CRTC1-dependent gene expression in the early, preplaque phase of Alzheimer disease-like pathology provides a molecular basis for the cognitive deficits that figure so prominently in early Alzheimer disease 26759481
2017-02-18 11:05:00 depolarization (which produced a robust increase in Ca(2+) signals) together with cAMP signaling resulted in a synergistic induction of Pacap mRNA through calcineurin and its substrate, cAMP-response element-binding protein (CREB)-regulated transcription coactivator 1. 27383213
2016-12-17 12:06:00 Our results provide evidence that CREB cofactor CRTC1 translocates into the nucleus of a distinct subset of hippocampal neurons during and following status epilepticus 26844388

名称对应

Type IDs
Synonymous Mect1, TORC-1, TORC1
Gene
UniProtKB-ID: CRTC1_RAT
UniprotKB: Q157S1
UniParc: UPI0000D8A1FE
EMBL: DQ538521
Ensembl: ENSRNOG00000022421
KO: rno:684527
Nucleutide sequences
EMBL-CDS: ABG23027.1
Ensembl_TRS: ENSRNOT00000038057
Protein sequencees
Ensembl_PRO: ENSRNOP00000030925
RefSeq: XP_006252998.1, NP_001040580.1
Others
UniRef100: UniRef100_Q157S1
UniRef90: UniRef90_Q68ED7
UniRef50: UniRef50_Q6UUV9
UniGene: Rn.208248

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