| Type | Description |
|---|---|
| Definition | SPT6 homolog, histone chaperone and transcription elongation factor |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:33:00 | SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation. | 33542242 |
| 2020-10-10 13:03:00 | SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells. | 32948765 |
| 2020-08-29 12:48:00 | Spt6 is a maintenance factor for centromeric CENP-A. | 32522980 |
| 2019-06-01 13:17:00 | SPT6 acts as a master regulator of Pol II elongation, favoring productive protein coding over non-productive and potentially deleterious lncRNA transcription. | 30449723 |
| 2019-03-09 10:44:00 | cryo-EM structure of an activated elongation complex of Sus scrofa Pol II and Homo sapiens DSIF, PAF and SPT6 was determined at 3.1 A resolution and compared to the structure of the paused elongation complex formed by Pol II, DSIF and NELF | 30135578 |
| Type | IDs |
|---|---|
| Synonymous | SPT6, SPT6H, emb-5 |
| Gene |
UniProtKB-ID:
SPT6H_HUMAN
UniprotKB:
Q7KZ85
UniParc:
UPI000015FFA7,
UPI000040B2D2,
UPI00003B5CB4
EMBL:
BC017105,
BC003696,
D79984,
BC136524,
BC150268,
BC136522,
CH471159,
U38658,
U38623,
U46691,
BC003692,
BC073963,
BC033074,
AF070532
Ensembl:
ENSG00000109111
KO:
hsa:6830
|
| Nucleutide sequences |
EMBL-CDS:
AAH33074.1,
EAW51117.1,
BAA11479.2,
AAC28631.1,
AAH03696.1,
AAI50269.1,
AAB18949.1,
AAI36525.1,
AAH73963.1,
AAH17105.1,
AAC50821.1,
AAI36523.1,
AAC99996.1,
AAH03692.1
Ensembl_TRS:
ENST00000314616,
ENST00000347486
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000338143,
ENSP00000319104
RefSeq:
XP_016880467.1,
XP_016880468.1,
NP_001307684.1,
XP_016880469.1,
NP_003161.2
|
| Others |
UniRef100:
UniRef100_Q7KZ85
UniRef90:
UniRef90_Q7KZ85
UniRef50:
UniRef50_Q7KZ85
UniGene:
Hs.250429
CCDS:
CCDS32596.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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