| Type | Description |
|---|---|
| Definition | NPC intracellular cholesterol transporter 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-02-02 11:45:00 | these data demonstrate the benefit of a one-time intracisternal administration of AAVrh.10-mNpc2-HA as a life-long treatment for Niemann-Pick type C2 disease | 29655638 |
| 2018-09-01 12:14:00 | accumulation of free cholesterol in late endosomes/lysosomes of Arf6 knockout mouse embryonic fibroblasts results from mistrafficking of Niemann-Pick type C protein | 27336679 |
| 2018-04-21 11:14:00 | complex contributes to intracellular cholesterol transport by targeting NPC2 to lysosomes in a CI-MPR-dependent manner. | 28658628 |
| 2017-09-02 10:41:00 | AAV9-mediated NPC1 delivery significantly promoted Purkinje cell survival, restored locomotor activity and coordination, and increased the lifespan of NPC1(-/-) mice. Our work suggests that AAV-based gene therapy is a promising means to treat NPC disease. | 28053186 |
| 2016-06-04 11:51:00 | These findings show that NPC2 secreted by premalignant lung tumours suppresses immature macrophage-lineage cell recruitment to the microenvironment in a paracrine manner. | 26183450 |
| Type | IDs |
|---|---|
| Synonymous | 2700012J19Rik, AA408070, AU045843, HE1 |
| Gene |
UniProtKB-ID:
NPC2_MOUSE
UniprotKB:
Q9Z0J0
UniParc:
UPI00000018B9
EMBL:
AK170327,
AK158624,
BC003471,
AK151133,
AK167869,
AK165263,
AK008603,
AK153203,
AK151067,
AB021289,
AK009127,
BC007190,
AK153020
Ensembl:
ENSMUSG00000021242
KO:
mmu:67963
|
| Nucleutide sequences |
EMBL-CDS:
BAE30141.1,
BAE41721.1,
BAE30083.1,
AAH03471.1,
BAE38111.1,
BAE39885.1,
BAE31654.1,
BAE34585.1,
BAA35183.1,
BAE31803.1,
BAB25771.1,
AAH07190.1,
BAB26090.1
Ensembl_TRS:
ENSMUST00000021668
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000021668
RefSeq:
NP_075898.1
|
| Others |
UniRef100:
UniRef100_Q9Z0J0
UniRef90:
UniRef90_Q9Z0J0
UniRef50:
UniRef50_Q9Z0J0
UniGene:
Mm.282556
CCDS:
CCDS26050.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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