| Type | Description |
|---|---|
| Definition | GIPC PDZ domain containing family, member 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-02-24 10:17:00 | GIPC1 forms a domain-swapped dimer in an autoinhibited conformation that hinders binding of both PlexinD1 and myosin VI. PlexinD1 binding to GIPC1 releases the autoinhibition, promoting its interaction with myosin VI. GIPCs and myosin VI interact through two distinct interfaces and form an open-ended alternating array. | 28537552 |
| 2016-07-30 11:29:00 | Down-regulation of endogenous GIPC1 is sufficient to inhibit the development of eye field cells from embryonic stem cells. | 26013465 |
| 2013-10-19 12:18:00 | Higher ratios of PSD-95/GluN2B and GAIP-interacting protein C-terminus (GIPC)/GluN2B were associated with poorer learning index scores across all ages. | 23884936 |
| 2012-12-08 10:25:00 | findings identify Gipc1 as a new interactor for Vangl2; show that a myosin VI-Gipc1 protein complex can regulate Vangl2 traffic in heterologous cells; results indicate a broad role for Gipc1 in the development of both stereociliary bundles and cell polarization | 22991442 |
| 2012-11-24 10:30:00 | TGFbetaR3 interaction with GIPC1 is critical for regulating invasion and growth factor responsiveness in epicardial cells, and dysregulation of epicardial cell proliferation and invasion contributes to failed coronary vessel development in Tgfbr3(-/-) mice | 21871877 |
| Type | IDs |
|---|---|
| Synonymous | GIPC, Glut1CIP, Rgs19ip1, Semcap1, TIP-2, TaxIP2 |
| Gene |
UniProtKB-ID:
GIPC1_MOUSE
UniprotKB:
Q9Z0G0
UniParc:
UPI000000417F
EMBL:
BC003490,
AF061263,
AF089818,
AF104358,
AK086506
Ensembl:
ENSMUSG00000019433
KO:
mmu:67903
|
| Nucleutide sequences |
EMBL-CDS:
AAC72311.1,
AAH03490.1,
AAD12262.1,
BAC39680.1,
AAC67550.1
Ensembl_TRS:
ENSMUST00000019577
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000019577
RefSeq:
XP_030099599.1,
NP_061241.1
|
| Others |
UniRef100:
UniRef100_Q9Z0G0
UniRef90:
UniRef90_Q9Z0G0
UniRef50:
UniRef50_Q9Z0G0
UniGene:
Mm.20945
CCDS:
CCDS22457.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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