| Type | Description |
|---|---|
| Definition | coiled-coil domain containing 80 |
| Date | Results | Publications |
|---|---|---|
| 2019-04-20 11:01:00 | Here, we showed that CCDC80 inhibited ERK1/2 activation, decreased TET2 expression and TET2-mediated DNA demethylation, and then promoted DNA methylation of the LPL gene. Consequently, CCDC80 reduced LPL expression and activity, leading to increased plasma TG levels and enhanced atherosclerotic lesions area, which at least partially involved FOXO3a. | 30439364 |
| 2019-03-23 12:04:00 | The results demonstrate DRO1 to be a strong tumor suppressor in the chemically induced colon carcinogenic mouse model. Additionally, DRO1 inhibits colitis-associated colon cancer formation and plays a putative role for in inflammatory bowel disease. | 29901779 |
| 2017-11-18 13:52:00 | DRO1 is a crucial regulator of energy homeostasis in vivo and functions as an inhibitor of adipogenesis in primary cells. | 27645901 |
| 2015-07-25 10:40:00 | This report characterizes a new mouse model for the study of colorectal cancer and establishes DRO1 (CCDC80) as a tumor suppressor via a mechanism involving ERK phosphorylation. | 25053805 |
| 2015-05-23 11:04:00 | Ccdc80 is a novel betacat-regulated gene in adrenocortical cells | 25029241 |
| Type | IDs |
|---|---|
| Synonymous | 2610001E17Rik, DRO1, Ssg1, Urb |
| Gene |
UniProtKB-ID:
CCD80_MOUSE
UniprotKB:
Q8R2G6
UniParc:
UPI0000192CD1
EMBL:
AK020169,
AK132178,
AK032359,
BC022704,
BC058751,
BC096487,
AK009795,
AK011256,
AB075019
Ensembl:
ENSMUSG00000022665
KO:
mmu:67896
|
| Nucleutide sequences |
EMBL-CDS:
BAC27834.1,
BAB26508.1,
AAH58751.1,
BAE21015.1,
BAB32018.1,
BAB27498.1,
AAH22704.1,
AAH96487.1,
BAB85613.1
Ensembl_TRS:
ENSMUST00000099498,
ENSMUST00000061050
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000058752,
ENSMUSP00000097097
RefSeq:
NP_080715.2,
XP_006522563.1,
XP_006522561.1,
XP_006522564.1,
XP_006522562.1
|
| Others |
UniRef100:
UniRef100_Q8R2G6
UniRef90:
UniRef90_Q8R2G6
UniRef50:
UniRef50_Q8R2G6
UniGene:
Mm.181074
CCDS:
CCDS28192.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员