| Type | Description |
|---|---|
| Definition | alkB homolog 8, tRNA methyltransferase |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:53:00 | Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming(). | 31765888 |
| 2016-04-02 10:18:00 | Alkbh8 and tRNA modifications as central regulators of cellular oxidative stress responses in mammalian systems. | 26147969 |
| 2013-09-06 09:40:00 | Many eukaryotic tRNAs contain the wobble modification 5-methoxycarbonylmethyl-uridine (mcm5U). It is demonstrated that (R)- and (S)-5-methoxycarbonylhydroxymethyluridine (mchm5U), hydroxylated forms of mcm(5)U, are present in mammalian tRNA-Arg(UCG), and tRNA-Gly(UCC), respectively. It is shown that the hydroxylation reaction leading to the formation of (S)-mchm5U is catalyzed by the oxygenase (AlkB) domain of ALKBH8. | 21285950 |
| 2013-09-06 09:37:00 | The methyltransferase domain of ALKBH8 is demonstrated to be a functional homologue of the Saccharomyces cerevisiae Trm9 protein, mediating the last step in the formation of the wobble uridine modification 5-methoxycarbonylmethyl-uridine in tRNA. This modification is shown to be important for efficient selenoprotein synthesis. ALKBH8 knock-out mice are generated and described. | 20123966 |
| 2011-10-22 11:39:00 | The AlkB domain of ALKBH8 specifically hydroxylates mcm(5)U into (S)-mchm(5)U in tRNA-Gly(UCC). | 21285950 |
| Type | IDs |
|---|---|
| Synonymous | 4930562C03Rik, 8030431D03Rik, 9430088N01Rik, Abh8 |
| Gene |
UniProtKB-ID:
ALKB8_MOUSE
UniprotKB:
Q80Y20
UniParc:
UPI00005B1C88,
UPI000018FE29,
UPI000002272F
EMBL:
AK160783,
AK081459,
BC050863,
AK020197
Ensembl:
ENSMUSG00000025899
KO:
mmu:67667
|
| Nucleutide sequences |
EMBL-CDS:
AAH50863.1,
BAC38223.1,
BAE36007.1,
BAB32026.1
Ensembl_TRS:
ENSMUST00000211933,
ENSMUST00000053407,
ENSMUST00000212294,
ENSMUST00000165105
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000148653,
ENSMUSP00000125996,
ENSMUSP00000061511,
ENSMUSP00000148380
RefSeq:
XP_006509944.1,
XP_036011094.1,
XP_006509942.1,
XP_006509946.1,
XP_006509943.1,
XP_036011095.1,
NP_080579.1,
XP_036011096.1,
XP_006509945.1
|
| Others |
UniRef100:
UniRef100_Q80Y20
UniRef90:
UniRef90_Q80Y20
UniRef50:
UniRef50_Q80Y20
UniGene:
Mm.116968,
Mm.440994
CCDS:
CCDS22792.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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