| Type | Description |
|---|---|
| Definition | chromatin licensing and DNA replication factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2017-06-24 10:16:00 | conserved arginine residues play critical roles in interaction with Geminin and Mcm that are crucial for proper conformation of the complexes and its licensing activity. | 26940553 |
| 2017-04-22 12:19:00 | Study shows that ablation of Geminin induces massive rereplication as a result of unrestrained Cdt1 activity in embryonic stem cells, whereas it has no such effect in embryonic fibroblasts in which alternative regulation of Cdt1 activity is intact. | 28296014 |
| 2014-01-04 12:28:00 | This study reveals a conserved new regulatory Cdt1 domain crucial for proper DNA licensing activity. | 23817338 |
| 2010-06-28 11:42:00 | Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase Mcm proteins. | 20335175 |
| 2010-02-15 11:25:00 | Determined the structures of mCdt1CS (mCdt1C_small; residues 452 to 557) and mCdt1CL (mCdt1C_large; residues 420 to 557) using X-ray crystallography and NMR. This study reveals that Cdt1 is formed with a tandem repeat of the winged helix domain. | 19722278 |
| Type | IDs |
|---|---|
| Synonymous | 2610318F11Rik, AW545653, C76791, DUP, Ris2 |
| Gene |
UniProtKB-ID:
CDT1_MOUSE
UniprotKB:
Q8R4E9
UniParc:
UPI0000020FA4
EMBL:
BC024485,
BC048076,
AF477990,
AK028287,
AK083015,
AB086655,
AK049163,
AF477481
Ensembl:
ENSMUSG00000006585
KO:
mmu:67177
|
| Nucleutide sequences |
EMBL-CDS:
AAH24485.1,
BAC22085.1,
BAC38731.1,
AAH48076.1,
AAL88446.1,
AAL82630.1,
BAC25859.1,
BAC33579.1
Ensembl_TRS:
ENSMUST00000006760
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000006760
RefSeq:
NP_080290.3
|
| Others |
UniRef100:
UniRef100_Q8R4E9
UniRef90:
UniRef90_Q8R4E9
UniRef50:
UniRef50_Q8R4E9
UniGene:
Mm.21873
CCDS:
CCDS22741.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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