| Type | Description |
|---|---|
| Definition | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-02-23 11:31:00 | In both mouse keratinocytes and HaCaT cells, Brm deficiency led to an increased cell population growth following ultraviolet radiation (UVR) exposure compared to cells with normal levels of Brm. The loss of Brm in keratinocytes exposed to UVR enables them to resume proliferation while harboring DNA photolesions, leading to an increased fixation of mutations and, consequently, increased carcinogenesis. | 30522882 |
| 2018-06-23 11:40:00 | PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors. | 29087303 |
| 2017-06-03 12:18:00 | BRG1/BRM and c-MYC have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene in cancer. | 28232072 |
| 2017-01-28 11:33:00 | SWI/SNF chromatin remodeler subunits Brg1 and Brm are expressed differentially during drug-induced liver injury and regeneration in a mouse model. | 27097303 |
| 2017-01-28 11:13:00 | these findings described a role for BRG1 and BRM in mitochondrial quality control, by regulating mitochondrial number, mitophagy, and mitochondrial dynamics not previously recognized in the adult cardiomyocyte | 27039070 |
| Type | IDs |
|---|---|
| Synonymous | 2610209L14Rik, SNF2alpha, Snf2l2, brahma, brm |
| Gene |
UniProtKB-ID:
SMCA2_MOUSE,
Q9D007_MOUSE,
H3BK47_MOUSE,
F2Z4A9_MOUSE,
H3BLH0_MOUSE
UniprotKB:
Q6DIC0,
Q9D007,
H3BK47,
F2Z4A9,
H3BLH0
UniParc:
UPI00024675E9,
UPI00001ECDC7,
UPI00003BA2FA,
UPI000042B0CA,
UPI00000224A2
EMBL:
BC075641,
AC118472,
AC118249,
AK011935
Ensembl:
ENSMUSG00000024921
KO:
mmu:67155
|
| Nucleutide sequences |
EMBL-CDS:
AAH75641.1,
BAB27925.1
Ensembl_TRS:
ENSMUST00000112637,
ENSMUST00000208589,
ENSMUST00000208751,
ENSMUST00000176475,
ENSMUST00000209085,
ENSMUST00000025862,
ENSMUST00000176030
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000146890,
ENSMUSP00000146924,
ENSMUSP00000108256,
ENSMUSP00000146994,
ENSMUSP00000135248,
ENSMUSP00000025862,
ENSMUSP00000135784
RefSeq:
NP_035546.2,
XP_006527348.1,
XP_036017556.1,
XP_006527347.1,
XP_030106911.1,
XP_030106907.1,
XP_006527349.1,
NP_001334368.1,
XP_006527344.1,
XP_030106906.1,
XP_006527346.1,
XP_006527352.1,
XP_036017557.1,
XP_030106910.1,
XP_006527345.1,
NP_080279.1,
XP_036017560.1,
XP_017173765.1,
XP_017173766.1,
XP_030106905.1,
XP_017173767.1,
XP_030106909.1,
XP_006527351.1,
XP_006527354.1
|
| Others |
UniRef100:
UniRef100_A0A140LHP6,
UniRef100_F2Z4A9,
UniRef100_H3BLH0,
UniRef100_Q6DIC0
UniRef90:
UniRef90_A0A287D2G2,
UniRef90_P51531
UniRef50:
UniRef50_P51531,
UniRef50_A0A287D2G2
UniGene:
Mm.491146
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员