| Type | Description |
|---|---|
| Definition | squalene epoxidase |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 12:20:00 | squalene directly bound to the N100 region, thereby reducing interaction with and ubiquitination by MARCH6 | 32170014 |
| 2020-07-04 12:35:00 | OSBPL2 deficiency upregulates SQLE expression and increases the accumulation of cholesterol and cholesteryl ester by suppressing AMPK signalling, which provides new evidence of the connection between OSBPL2 and cholesterol synthesis. | 31356817 |
| 2020-03-21 12:40:00 | VCP plays a key role in ERAD that contributes to the cholesterol-mediated regulation of Squalene monooxygenase. | 31471528 |
| 2020-03-07 12:47:00 | Further survival analysis indicated that high expression of SQLE indicated poor prognosis in lung squamous cell carcinoma. Our study presents novel evidence of potential biomarkers or therapeutic targets for lung SCC therapy and prognosis. | 30734525 |
| 2019-12-14 10:18:00 | findings reveal the degron architecture of SM N100, introducing the role of non-canonical ubiquitination sites and deepening our molecular understanding of how SM is degraded in response to cholesterol. | 30940729 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
ERG1_HUMAN,
Q5HYI4_HUMAN
UniprotKB:
Q14534,
Q5HYI4
UniParc:
UPI00004C4133,
UPI0000073EEE
EMBL:
D78130,
FJ695197,
AF098865,
CH471060,
BX647605,
BX647400,
AC009908,
D78129,
BC017033,
AK313384
Ensembl:
ENSG00000104549
KO:
hsa:6713
|
| Nucleutide sequences |
EMBL-CDS:
EAW92079.1,
BAA22372.1,
BAG36182.1,
AAH17033.1,
AAD10823.1,
BAA11209.1,
CAI46076.1
Ensembl_TRS:
ENST00000265896
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000265896
RefSeq:
XP_011515548.1,
NP_003120.2
|
| Others |
UniRef100:
UniRef100_Q14534,
UniRef100_Q5HYI4
UniRef90:
UniRef90_A0A2K6G501,
UniRef90_Q14534
UniRef50:
UniRef50_Q14534
UniGene:
Hs.71465
CCDS:
CCDS47918.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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