| Type | Description |
|---|---|
| Definition | microtubule associated serine/threonine kinase-like |
| Date | Results | Publications |
|---|---|---|
| 2020-12-19 13:44:00 | The Greatwall kinase safeguards the genome integrity by affecting the kinome activity in mitosis. | 32978522 |
| 2019-09-21 12:13:00 | reveal an unexpected role of Mastl in actin cytoskeletal dynamics in postmitotic cells and suggest that the thrombocytopenia-associated mutation in MASTL is a pathogenic dominant mutation that mimics decreased PP2A activity resulting in altered phosphorylation of cytoskeletal regulatory pathways. | 30252678 |
| 2019-01-05 11:28:00 | Findings reveal the role of RSK in mouse oocytes, showing that the RSK-MASTL pathway allows mammalian-specific prolonged meiotic exit and ensures the faithful conversion from sperm to paternal pronuclei. | 30293837 |
| 2017-05-27 11:32:00 | using in vitro dephosphorylation assays, we demonstrate that Mastl promotes persistent MPS1 phosphorylation by inhibiting PP2A/B55-mediated MPS1 dephosphorylation rather than affecting Cdk1 kinase activity. Our findings establish a key regulatory function of the Greatwall kinase/Mastl - PP2A/B55 pathway in preventing premature SAC silencing | 27631493 |
| 2014-11-29 10:49:00 | Mastl is required for the timely activation of anaphase-promoting complex/cyclosome to allow meiosis I exit and for the rapid rise of Cdk1 activity. | 25246615 |
| Type | IDs |
|---|---|
| Synonymous | 2700091H24Rik, C88295, GW, GWL, MAST-L, THC2 |
| Gene |
UniProtKB-ID:
GWL_MOUSE
UniprotKB:
Q8C0P0
UniParc:
UPI00020530AD,
UPI00001EEAF8
EMBL:
AK078365,
CH466542,
BC066834,
BC086483,
BC103779,
AK006448,
AK030140,
AL845257,
AK012597
Ensembl:
ENSMUSG00000026779
KO:
mmu:67121
|
| Nucleutide sequences |
EMBL-CDS:
AAI03780.1,
BAC37239.1,
EDL08150.1,
AAH86483.1,
BAB24595.1,
BAB28343.2,
BAC26804.1,
AAH66834.1
Ensembl_TRS:
ENSMUST00000028119
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000028119
RefSeq:
XP_017174703.1,
XP_030107837.1,
NP_080255.3
|
| Others |
UniRef100:
UniRef100_Q8C0P0
UniRef90:
UniRef90_Q8C0P0
UniRef50:
UniRef50_Q8C0P0
UniGene:
Mm.253721
CCDS:
CCDS15727.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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