| Type | Description |
|---|---|
| Definition | Fanconi anemia, complementation group L |
| Date | Results | Publications |
|---|---|---|
| 2013-03-27 09:46:00 | The authors report the structure of the human FANCL central domain and show that the RING domain is necessary and sufficient for E2 binding. | 21775430 |
| 2013-03-27 09:45:00 | Using HeLa cells and lymphoblasts from Fanconi anemia patients, the authors characterize PHF9 (FANCL) as a ubiquitin ligase and show it is essential for FANCD2 monoubiquitination. The authors state that PHF9 is the human homolog of mouse Pog (Fancl). | 1297335 |
| 2012-09-29 11:08:00 | FANCL increases the activity and expression of beta-catenin, a key pluripotency factor in hematopoietic stem cells. | 22653977 |
| 2011-06-25 15:02:00 | UBE2W regulates FANCD2 monoubiquitination by mechanisms different from UBE2T and HRR6. | 21229326 |
| 2011-02-14 12:11:00 | Fancl is associated with acute lung injury | 21297076 |
| Type | IDs |
|---|---|
| Synonymous | 2010322C19Rik, AW554273, B230118H11Rik, Phf9, Pog, gcd |
| Gene |
UniProtKB-ID:
FANCL_MOUSE
UniprotKB:
Q9CR14
UniParc:
UPI00001D8A73,
UPI0000020DB0
EMBL:
BC066181,
AK168538,
AK008605,
AK011520,
AF513619,
BC032876,
AK018018,
AK011903,
AK011752,
AK076017
Ensembl:
ENSMUSG00000004018
KO:
mmu:67030
|
| Nucleutide sequences |
EMBL-CDS:
BAB25772.1,
AAH32876.1,
BAB31039.1,
BAE40416.1,
BAB27820.1,
BAB27674.1,
AAN64921.1,
BAB27906.1,
BAC36123.1,
AAH66181.1
Ensembl_TRS:
ENSMUST00000004120,
ENSMUST00000109509
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000105135,
ENSMUSP00000004120
RefSeq:
NP_080199.1,
NP_001264202.1
|
| Others |
UniRef100:
UniRef100_Q9CR14
UniRef90:
UniRef90_Q9CR14
UniRef50:
UniRef50_Q9CR14
UniGene:
Mm.18875
CCDS:
CCDS70152.1,
CCDS24485.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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