| Type | Description |
|---|---|
| Definition | small proline rich protein 2A |
| Date | Results | Publications |
|---|---|---|
| 2019-08-31 12:55:00 | Assessment of SPRR2A protein expression in a clinical cohort of patients with head and neck squamous cell carcinoma (HNSCC) confirmed common SPRR2A downregulation in primary tumors and lymph node metastases, but not in normal tissue. High expression of SPRR2A in lymph node metastases was, along with nonoropharyngeal location of the primary tumor, an independent prognostic factor for regional disease recurrence. | 30108165 |
| 2018-05-19 10:36:00 | Expression of SPRR1 and of SPRR2A is increased in mucosal samples from patients with chronic rhinosinusitis and appeared as a downstream result of TNF alpha modulation, which possibly resulted in epithelial barrier dysfunction. | 28859701 |
| 2014-05-03 10:56:00 | SPRR2a modulates ZEB-1 signaling by way of miR-200c/141-associated epithelial mesenchyme transition through SH3-domain networks and contributes to benign and malignant wound-healing responses. | 24123265 |
| 2014-01-18 10:34:00 | SPRR2A-associated tumor behavior was mimicked by MUC1 shRNA, which induced EMT and, like SPRR2A+ cells, showed reduced metastatic capabilities | 23728799 |
| 2013-03-02 10:50:00 | SPRR2A functions as a suppressor of p53-dependent transcriptional activity, which otherwise might impede cellular processes needed for epithelial wound repair responses. | 22731250 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
SPR2A_HUMAN
UniprotKB:
P35326
UniParc:
UPI0000135D6D
EMBL:
BC096110,
CH471121,
BC096108,
X53064,
BC096111,
AK311939,
AL356867,
BC128049,
BC096109
Ensembl:
ENSG00000241794
KO:
hsa:6700
|
| Nucleutide sequences |
EMBL-CDS:
EAW53347.1,
AAH96108.1,
AAH96111.1,
AAI28050.1,
BAG34880.1,
AAH96109.1,
AAH96110.1,
CAA37239.1,
EAW53346.1
Ensembl_TRS:
ENST00000392653
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000376423
RefSeq:
NP_005979.1
|
| Others |
UniRef100:
UniRef100_P35326
UniRef90:
UniRef90_P35326
UniRef50:
UniRef50_P35326
UniGene:
Hs.355542
CCDS:
CCDS1034.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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