| Type | Description |
|---|---|
| Definition | polybromo 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-10-20 11:59:00 | Data show that 100% of von Hippel-Lindau tumor suppressor protein (Vhl) / polybromo 1 protein (Pbrm1) knockout mice developed renal cancers by 20 months of age. | 29229903 |
| 2018-04-28 11:32:00 | We conditionally targeted Bap1 and Pbrm1 (with Vhl) in the mouse using several Cre drivers.Sglt2 and Villin proximal convoluted tubule drivers failed to cause tumorigenesis, challenging the conventional notion of Clear cell renal cell carcinoma (ccRCC)origins | 28473526 |
| 2018-04-28 10:07:00 | dual inactivation of Vhl with either Bap1 or Pbrm1 results in faithful genetically engineered murine models of clear cell renal cell carcinoma (ccRCC). | 28765116 |
| 2017-12-02 11:42:00 | Data suggest BAF180 protein as a critical regulator of cellular senescence and HSC homeostasis, which is at least partially regulated through BAF180-mediated suppression of cell cycle regulator p21 expression. | 26992241 |
| 2017-11-26 00:32:00 | kidney-specific deletion of Vhl and Pbrm1, but not either gene alone, results in bilateral, multifocal, transplantable clear cell kidney cancers. | 28329682 |
| Type | IDs |
|---|---|
| Synonymous | 2610016F04Rik, AI507524, BAF180, Pb1 |
| Gene |
UniProtKB-ID:
F8VQD1_MOUSE
UniprotKB:
F8VQD1
UniParc:
UPI0000607145
EMBL:
AC154446,
AC154727
Ensembl:
ENSMUSG00000042323
KO:
mmu:66923
|
| Nucleutide sequences |
Ensembl_TRS:
ENSMUST00000112098
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000107727
RefSeq:
NP_001074720.1,
NP_001346784.1,
NP_001346783.1,
NP_001346787.1,
NP_001346786.1,
NP_001346785.1
|
| Others |
UniRef100:
UniRef100_F8VQD1
UniRef90:
UniRef90_Q86U86-7
UniRef50:
UniRef50_Q86U86
UniGene:
Mm.27913
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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