| Type | Description |
|---|---|
| Definition | serine peptidase inhibitor, Kazal type 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 13:13:00 | Investigated whether tazarotene-induced gene 1 protein (TIG1) affects the activity of urokinase plasminogen-type activator, which is negatively regulated by serine peptidase inhibitor Kazal type 2 (SPINK2), potentially preventing epithelial mesenchymal transition and suppressing cell migration and invasion. | 31886233 |
| 2018-04-07 11:44:00 | These results demonstrate that SPINK2 is necessary to neutralize proteases during their cellular transit toward the acrosome and that its deficiency induces a pathological continuum ranging from oligoasthenoteratozoospermia in heterozygotes to azoospermia in homozygotes. | 28554943 |
| 2010-01-21 00:00:00 | Data showed that the expression level of SPINK2 is significantly elevated in most leukemia cell lines except B-lymphoblast TK-6 cells. Data demonstrated that Arg(24) at the P1 site is crucial for the specificity of SPINK2 on target enzyme. | 19422058 |
| 2008-03-13 08:51:00 | Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | 17333166 |
| Type | IDs |
|---|---|
| Synonymous | HUSI-II, SPGF29 |
| Gene |
UniProtKB-ID:
ISK2_HUMAN,
A0A024RD95_HUMAN,
D6RC51_HUMAN,
D6RI10_HUMAN,
A0A087WTA9_HUMAN
UniprotKB:
P20155,
A0A024RD95,
D6RC51,
D6RI10,
A0A087WTA9
UniParc:
UPI000020B920,
UPI000041362A,
UPI000299A05B,
UPI000011D59F
EMBL:
M84967,
M91438,
CR542135,
CH471057,
BC022514,
GU727622,
X57655,
AC022483,
AK312222
Ensembl:
ENSG00000128040
KO:
hsa:6691
|
| Nucleutide sequences |
EMBL-CDS:
CAG46932.1,
CAB37834.1,
ADU87624.1,
BAG35155.1,
EAX05513.1,
AAH22514.1,
AAB59431.1,
EAX05514.1
Gene_ORFName:
hCG_18772
Ensembl_TRS:
ENST00000248701,
ENST00000504762,
ENST00000506738,
ENST00000618802
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000248701,
ENSP00000423858,
ENSP00000425961,
ENSP00000477722
RefSeq:
NP_001258649.1,
XP_011532708.1,
NP_001258648.1,
NP_001258650.1,
NP_066937.1,
XP_011532707.1,
XP_024309959.1,
NP_001258647.1,
NP_001258651.1
|
| Others |
UniRef100:
UniRef100_P20155,
UniRef100_A0A087WTA9,
UniRef100_D6RI10,
UniRef100_D6RC51
UniRef90:
UniRef90_P20155,
UniRef90_A0A087WTA9,
UniRef90_G3RT93
UniRef50:
UniRef50_A0A087WTA9,
UniRef50_G3RT93,
UniRef50_P20155
UniGene:
Hs.98243
CCDS:
CCDS3508.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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