| Type | Description |
|---|---|
| Definition | Sp3 transcription factor |
| Date | Results | Publications |
|---|---|---|
| 2020-11-28 13:13:00 | Sp3 Cooperates with the Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein To Synergistically Activate Specific Viral and Cellular Gene Promoters. | 32641483 |
| 2020-04-11 12:42:00 | The authors identified that human papillomavirus type 8 E7 protein exerts control over cellular gene expression through Sp1/3 binding motifs, which may contribute to the virus-mediated keratinocyte transformation and subsequent fibronectin-dependent invasion. | 31299490 |
| 2019-06-15 11:17:00 | These findings suggest that the transcription of the b4GalT3 gene is regulated by differential DNA binding of Sp3 and Sp1 in neuroblastoma and lung cancer. The increased expression of b4GalT3 in neuroblastoma may be ascribed to the enhanced expression of Sp3, which is observed for various cancers. | 30561605 |
| 2018-07-28 10:29:00 | expression of the nearby cyclindependent kinase inhibitor 1C (CDKN1C) gene was revealed to be upregulated after SP3 knockdown in cells that possessed non-risk alleles. This suggests that CDKN1C is potentially one of the functional targets of SNP rs163184, which modulates the binding activity of the locus for Sp3 and Lsd1/Kdm1a | 29207083 |
| 2017-12-09 11:39:00 | Sp1, Sp3 and Sp4 are non-oncogene addiction (NOA) genes and are attractive drug targets for individual and combined cancer chemotherapies. | 26967243 |
| Type | IDs |
|---|---|
| Synonymous | SPR2 |
| Gene |
UniProtKB-ID:
SP3_HUMAN,
Q59FX5_HUMAN,
Q86TP0_HUMAN,
B7ZLN9_HUMAN
UniprotKB:
Q02447,
Q59FX5,
Q86TP0,
B7ZLN9
UniParc:
UPI00001C1D55,
UPI00001C1DCF,
UPI0001565474,
UPI000019B3E0,
UPI00004F6C6A,
UPI0001565473,
UPI0000509F08,
UPI0001565475,
UPI000189A7F3
EMBL:
BC126414,
BC042945,
AJ310752,
M97191,
AY441958,
AF494280,
AK304199,
AY070137,
BC143928,
AY441957,
X68560,
AB209334
Ensembl:
ENSG00000172845
KO:
hsa:6670
|
| Nucleutide sequences |
EMBL-CDS:
AAL58086.1,
AAM12875.1,
AAR30506.1,
AAI26415.1,
AAA36630.2,
BAG65079.1,
CAA48562.1,
CAC34575.1,
AAR30505.1,
BAD92571.1,
AAH42945.2,
AAI43929.1
Ensembl_TRS:
ENST00000310015
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000310301
RefSeq:
NP_001017371.3,
NP_001166183.1,
NP_003102.1
|
| Others |
UniRef100:
UniRef100_Q86TP0,
UniRef100_Q59FX5,
UniRef100_B7ZLN9,
UniRef100_Q02447
UniRef90:
UniRef90_Q86TP0,
UniRef90_Q02447,
UniRef90_Q02447-6
UniRef50:
UniRef50_Q02447,
UniRef50_A0A1S3WHD1
UniGene:
Hs.531587
CCDS:
CCDS46452.1,
CCDS2254.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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