| Type | Description |
|---|---|
| Definition | signal peptide peptidase like 2A |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 10:25:00 | SPPL2a/b negatively regulates LOX-1 signaling and atherosclerosis. | 30819724 |
| 2019-05-25 10:52:00 | Sppl2a-/- mice lack conventional dendritic cells, have CD4+ T cells that produce small amounts of IFN-gamma after BCG infection, and are highly susceptible to infection with BCG or Mycobacterium tuberculosis | 30127434 |
| 2017-05-20 14:31:00 | Study propose that elements within the transmembrane segment and the luminal juxtamembrane domain facilitate intramembrane proteolysis of CD74 by SPPL2a. | 26987812 |
| 2015-11-28 11:11:00 | SPPL2a-mediated processing of CD74 NTF is indispensable to maintain appropriate levels of tonic BCR signaling to promote B cell maturation. | 26157172 |
| 2014-10-04 10:58:00 | Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a). | 24872421 |
| Type | IDs |
|---|---|
| Synonymous | 2010106G01Rik, C130089K23Rik |
| Gene |
UniProtKB-ID:
SPP2A_MOUSE
UniprotKB:
Q9JJF9
UniParc:
UPI0000022BA4
EMBL:
AL928836,
AL732330,
CH466519,
BC026578,
AB041547
Ensembl:
ENSMUSG00000027366
KO:
mmu:66552
|
| Nucleutide sequences |
EMBL-CDS:
AAH26578.1,
EDL28169.1,
BAA95032.1
Gene_ORFName:
MNCb-3763
Ensembl_TRS:
ENSMUST00000028844
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000028844
RefSeq:
NP_075709.2,
XP_036018350.1,
XP_036018348.1,
XP_036018349.1
|
| Others |
UniRef100:
UniRef100_Q9JJF9
UniRef90:
UniRef90_Q9JJF9
UniRef50:
UniRef50_Q9JJF9
UniGene:
Mm.269928
CCDS:
CCDS16690.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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